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74 TABLETING


Compaction simulator improves


Gerd Hueffmann reports on a successful upscaling exercise using a compaction simulator


he work discussed here represents a practical example of using a


compaction simulator to create scalable compression data for a rotary press.


Te task description was as


follows: to establish a hardness/ compaction force profile for a pharmaceutical tablet (Olmesartan) in two different prescription strengths, while at the same time providing setting data for a specific rotary press (here a Kilian Synthesis 51D) at a defined speed setting. Te tool used was a


compaction simulator tablet press, in this case a Styl’One Evolution from Romaco Kilian.


Tableting requirements To fulfil all tableting requirements, this simulator is fully instrumented to measure


Strength 5mg 10mg 20mg 40mg


www.scientistlive.com Dosing


Tablet Weight (mg)


65.0 ± 7.5% 120.0 ± 7.5% 160.0 ± 7.5% 320.0 ± 5.0%


compaction forces (tamping force, pre- and main compaction force), as well as ejection forces and punch displacement. Compaction cycles can either be force- or displacement controlled to replicate all commercially available tablet press control systems.


As the task was to simulate


a rotary press the simulator was equipped with a force-feed fill shoe. Most important is the ability of the compaction simulator to replicate the compaction cycle of the rotary press in question/comparison at a given operational speed. For this purpose, unrestricted compaction profiles for any rotary press make and model can be created with the help of the compaction simulators’ control panel.


Thickness (mm)


2.75 ± 0.30 3.20 ± 0.30 3.60 ± 0.30 4.80 ± 0.40


Hardness (N)


20-70 20-80 20-80 40-130


OPERATION T


ROTARY PRESS


A compaction profile typically comprises of the following parameters that are in line with those of the simulated rotary press:


l Die Filling (time) l Pre-compression (force and de-aeration time)


l Main-compression (force and dwell time) l Ejection (force)


The trials Te trials were carried out on a Styl’One Evolution simulating a Kilian Synthesis 700 51D with 30rpm. Te setting for each punch as well as the results are listed below and right. Tree tablets were measured for each compression force setting. Below are the requested parameters from the client:


Diameter (mm)


6.0 ± 0.20 mm 7.0 ± 0.20 mm 8.0 ± 0.20 mm 9.6 ± 0.20 mm


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