62 BIOTECHNOLOGY
Stem cell patch advances C
Dr Jessica Daecke reports on how stem cell patches could represent a new therapy for heart diseases
hronic ischemic cardiac diseases can today be treated only
palliatively but there is no therapy available that restores function that has been lost. Cell-based therapeutic approaches, carried out by injection of stem cells into the heart suggest beneficial effects on cardiac function but are still hampered by the quick loss of the injected
cells and limited targeting of the cells to the damaged tissue.
Development of a new solution Now a cooperation of academic and industry partners in Germany and Spain brings forward a solution to immobilise therapeutic adipose-derived stem cells (ADSCs) at the site of damage: by seeding on a thin and highly biocompatible collagen membrane that can be sutured directly to the heart muscle. Te impacts of this
investigated advanced therapy medicinal product (ATMP) were assessed in a rat and a preclinical swine model for chronic myocardial infarct. “One week after suturing the collagen
cell carrier loaded with ADSCs to the site of damaged cardiac tissue, one quarter of cells had engrafted in the heart muscle, while in the group where ADSCs had been administered by injection, implanted cells were lost completely,” reports Felipe Prosper of the University of Navarra. “And most importantly, after four months the volume of blood pumped from the heart ventricle had increased by 15% – significantly more than in the control groups.” Te researchers ascribe
the improved heart function to several effects. Firstly and most importantly, they observe enhanced vascularisation near the infarcted zone. Secondly,
The improved cell engraftment and presumably favourable combination of secreted factors mediated by the collagen carrier drastically reduced the number of cells required for implantation.
www.scientistlive.com
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