TABLETING 85
PF Inc. (Pet Flavors, Inc.) was on the ground floor of this movement. Te company noted that acceptance of medication was determined not only by the animals, but also by the pet owners. Using taste-making and odour-masking technology, PF Inc. developed flavour bases that enhance the aroma and appearance of any medication.
Contributing to compliance are factors that impact pets, such as palatability, size, shape and texture (‘good’ mouth feel) plus the mode of administration. In
addition, human compliance increases when the medication is easy to administer, has a pleasing colour/smell, and doesn’t have to be given often.
Palatability can be measured by how frequently medicine is voluntarily consumed and the speed at which it is consumed. PF Inc has completed studies with over 300 canine palatable products and over 50 feline palatable products using its flavour bases. Overall product palatability for PF Inc flavour bases ranges from 95.0% to
Developing a continuous tableting process
A collaborative research project between Freeman Technology and GEA Pharma Systems is providing new insight to support the development of continuous tablet manufacturing processes, a long term goal for the pharmaceutical industry. Within the pharmaceutical
industry the replacement of batch tablet production units with continuous manufacturing suites has the potential to significantly improve efficiency and reduce costs. Freeman
Technology, a leader in powder testing instrumentation, and GEA, a specialist provider of pharmaceutical processing equipment, are combining their expertise to advance understanding in this area. A primary focus is to identify metrics that provide a sound basis for the effective control of continuous manufacturing processes. The production of tablets often
involves wet granulation of a fine powder blend, followed by compression of the resulting dried, milled and lubricated granules. In this research GEA’s ConsiGma 1 continuous granulation unit is being used to produce granules for tableting, which are then characterised using Freeman Technology’s FT4 Powder Rheometer. Direct correlations are observed
between the flow properties of the granules and critical quality attributes of finished tablets, such as hardness. These correlations highlight the potential of
99.9% free choice acceptance for dogs and 90.0% to 99.9% free choice acceptance for cats.
With increasing rates of pet ownership, longer life expectancy for companion animals and advances in animal health, there is a growing demand for highly palatable oral animal medicine. Tese oral formulations offer easy and convenient dosing and improve compliance, thereby directly influencing the health and wellbeing of today’s pets.
For more information ✔ at
www.scientistlive.com/eurolab
Palatants are specially designed to make pet medicine taste better, ensuring that pets receive the medicine they need.
Debora Nelson is QA/QC manager at Pet Flavors, Inc..
www.petflavors.com
dynamic powder testing as an at-line Process Analytical Technology (PAT) for continuous tablet manufacture. Building on early success in applying
powder flowability data to scope the design space for the ConsiGma 1, current goals are to establish links between wet granule flow properties and observed tablet weight variability at production speeds. Often sub-optimal granules
are associated with low manufacturing speeds and/or high weight variability in the finished product. A partial aim of the current work is to show how dynamic powder characterisation can be used to optimise continuous granulation so as to avoid these problems..
For more information visit
www.freemantech.co.uk
www.scientistlive.com
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