SECTION NAME 2
TABLETING 75
“For the development of Opadry amb II we identified and used a new technology to measure and substantiate the rate of moisture adsorption. We are pleased to be able to bring this product to market, helping our customers improve manufacturing efficiency with reduced production time, while improving final product quality and in-use shelf life,” noted Colorcon’s Cornelis van den Muyzenberg.
Te company has also launched an optimised aqueous acrylic enteric coating system called Acryl-EZE II, which uses Evonik’s globally accepted enteric polymer EUDRAGIT L100-55. Tis eliminates the need for plasticiser addition and can be applied at lower weight gains compared to existing Acryl-EZE systems. As such, it offers enteric performance over a wide range of pH media for acid-labile drug
formulations, as well as helping to prevent drug-induced stomach irritation.
Colorcon says the new system also reduces potential errors of raw material handling and application during manufacturing.
Also making advances in enteric delivery is Capsugel, with its intrinsically enteric capsule technology.
The importance of punch polishing P
unch polishing is a critical part of any tool care regime and, if carried out correctly, good polishing can help prolong the life of tablet
compression tooling. Recognising the importance of this process, I Holland, a leading manufacturer of tablet tooling for the pharmaceutical and nutraceutical industries, has developed the MF80. The company says the new tool is its most advanced polisher yet. The company recommends a seven step PharmaCare
standard operating procedure (SOP) for punch and die maintenance – and polishing is one of these steps.
PharmaCare equipment manager Andy Dumelow
explains: “Automated polishing is becoming recognised as the preferred method of effectively polishing tablet tooling. There are clear advantages in terms of operational performance, as well as economic benefits. Firstly, automated polishing eliminates any potential variation that the manual process can bring, as punches can be polished to a micro fine, consistent finish achieved across a batch of punches within a mere 20-minute cycle, freeing up manpower within the tool room to focus on other tasks. In contrast, the other
method of manual polishing is essentially a destructive process where over polishing and the subsequent removal of material is quite commonplace. It is very difficult to achieve a consistent finish across a tool set with a manual polishing process.” Dumelow also notes that the MF80 has been
designed to help increase polishing capacity. With an 80 litre drum and the ability to hold up to 17 B or 12 D punches per holder, it gives a maximum of 85 B or 60 D punches per polishing cycle – which he says is a huge benefit in today’s production environment.
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A big challenge is to protect tablets against environmental moisture levels and guard core active ingredients.
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