®
150 mg/mL ANTIMICROBIAL NADA 141-328, Approved by FDA For subcutaneous injection in beef and non-lactating dairy cattle only. Not for use in female dairy cattle 20 months of age or older or in calves to be processed for veal.
(gamithromycin)
Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. READ ENTIRE BROCHURE CAREFULLY BEFORE USING THIS PRODUCT.
INDICATIONS ZACTRAN is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis in beef and non-lactating dairy cattle. ZACTRAN is also indicated for the control of respiratory disease in beef and non-lactating dairy cattle at high risk of developing BRD associated with Mannheimia haemolytica and Pasteurella multocida.
CONTRAINDICATIONS As with all drugs, the use of ZACTRAN is contraindicated in animals previously found to be hypersensitive to this drug.
WARNING: FOR USE IN CATTLE ONLY. NOT FOR USE IN HUMANS. KEEP THIS AND ALL DRUGS OUT OF REACH OF CHILDREN. NOT FOR USE IN CHICKENS OR TURKEYS. The material safety data sheet (MSDS) contains more detailed occupational safety information. To report adverse effects, obtain an MSDS or for assistance, contact Merial at 1-888-637-4251.
RESIDUE WARNINGS: Do not treat cattle within 35 days of slaughter. Because a discard time in milk has not been established, do not use in female dairy cattle 20 months of age or older. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.
PRECAUTIONS The effects of ZACTRAN on bovine reproductive performance, pregnancy, and lactation have not been determined. Subcutaneous injection of ZACTRAN may cause a transient local tissue reaction in some cattle that may result in trim loss of edible tissues at slaughter.
ADVERSE REACTIONS Transient animal discomfort and mild to moderate injection site swelling may be seen in cattle treated with ZACTRAN.
EFFECTIVENESS The effectiveness of ZACTRAN for the treatment of BRD associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni was demonstrated in a field study conducted at four geographic locations in the United States. A total of 497 cattle exhibiting clinical signs of BRD were enrolled in the study. Cattle were administered ZACTRAN (6 mg/kg BW) or an equivalent volume of sterile saline as a subcutaneous injection once on Day 0. Cattle were observed daily for clinical signs of BRD and were evaluated for clinical success on Day 10. The percentage of successes in cattle treated with ZACTRAN (58%) was statistically significantly higher (p<0.05) than the percentage of successes in the cattle treated with saline (19%). The effectiveness of ZACTRAN for the treatment of BRD associated with M. bovis was demonstrated independently at two U.S. study sites. A total of 502 cattle exhibiting clinical signs of BRD were enrolled in the studies. Cattle were administered ZACTRAN (6 mg/ kg BW) or an equivalent volume of sterile saline as a subcutaneous injection once on Day 0. At each site, the percentage of successes in cattle treated with ZACTRAN on Day 10 was statistically significantly higher than the percentage of successes in the cattle treated with saline (74.4% vs. 24% [p <0.001], and 67.4% vs. 46.2% [p = 0.002]). In addition, in the group of calves treated with gamithromycin that were confirmed positive for M. bovis (pre-treatment nasopharyngeal swabs), there were more calves at each site (45 of 57 calves, and 5 of 6 calves) classified as successes than as failures. The effectiveness of ZACTRAN for the control of respiratory disease in cattle at high risk of developing BRD associated with Mannheimia haemolytica and Pasteurella multocida was demonstrated in two independent studies conducted in the United States. A total of 467 crossbred beef cattle at high risk of developing BRD were enrolled in the study. ZACTRAN (6 mg/kg BW) or an equivalent volume of sterile saline was administered as a single subcutaneous injection within one day after arrival. Cattle were observed daily for clinical signs of BRD and were evaluated for clinical success on Day 10 post-treatment. In each of the two studies, the percentage of successes in the cattle treated with ZACTRAN (86% and 78%) was statistically significantly higher (p = 0.0019 and p = 0.0016) than the percentage of successes in the cattle treated with saline (36% and 58%).
Marketed by Merial Limited 3239 Satellite Blvd., Duluth, GA 30096-4640 U.S.A. Made in Austria
®ZACTRAN is a registered trademark of Merial Limited. ©2012 Merial Limited. All rights reserved. Rev. 03/2012
respiration rate slows after the heat of the day is past. Abnormal breathing may be au-
dible if the animal is having trouble drawing air into the lungs through narrowed airways, wheezing, or having trouble forcing it out, grunt- ing, due to compromised lungs. A respiratory problem may also cause the animal to make exaggerated fl ank movements.
Eating habits and digestion Another clue regarding health
or sickness is whether eating habits are normal. “Look for lack of gut fi ll,” says Dr. Charlie Deyhle, Can- yon, who has practiced veterinary medicine for 36 years and consults with ranches and feedyards. “Sick cattle don’t eat, and cattle
that don’t eat get sick. This may be infl uenced by what you are feed- ing them, but most cattle go off feed if they are sick. A calf might nibble a little, but isn’t consuming enough nutrition,” says Deyhle. The sick calf might go to the feed bunk with his buddies because he feels safer with the group and wants to be where they are, but he may just stand there and not eat much. On closer inspection, does the
animal chew and swallow properly, or is swallowing painful? Is saliva or feed drooling or dropping from the mouth? Is she unable to belch up and chew the cud? Is cud spilling from the mouth? Is she coughing up food or regurgitating stomach con- tents out the nostrils? Is there any grunting or extra effort involved in belching up the cud? Is she grind- ing her teeth? Overactive “chew- ing” and teeth grinding is a sign of belly pain, especially in calves. A calf with a digestive problem or gut pain will often grind his teeth. “What does their fecal material look like? Is it red, brown, black,
ZACTRAN-PI-thirdpage-MBovis_THE
CATTLEMAN_FA.indd 11/3/13 11:38 AM 96 The Cattleman September 2013
transparent and horizontal, such as watery diarrhea shooting out in a stream, or normal?” asks Deyhle. The color, texture and consistency of calf feces or cow manure can tell you a lot about what the animal is eating and the health of that animal.
Defecation and urination Are defecation and urination
normal? With some digestive prob- lems the animal becomes consti- pated. The act of passing manure may be diffi cult and prolonged, with straining and pain. Manure may be fi rm and dry, or absent if there is a gut blockage. If you can get the cow up, make
her walk and follow her to see if she passes manure. If she doesn’t, there may be a problem. At the other extreme is diarrhea. Severe diar- rhea in some instances, such as in coccidiosis, may cause so much irritation to the rectum that the animal strains continually and may prolapse the rectum. Urination may be absent or
scanty if she is dehydrated or has not been drinking enough. Urina- tion may be diffi cult if there’s ob- struction or partial blockage of the urinary tract, such as a bladder stone, or infl ammation of bladder or urethra. The animal may dribble small amounts of urine, or remain in urinating position for a long time, or kick at the belly in pain, or stand stretched.
Don’t miss the small clues Much information can be
gleaned from noticing all you can about an animal’s general attitude and behavior from a distance, while she is still preoccupied with her own problems — before she focuses attention on you and becomes dis- tracted. When checking cattle, try to get
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