NEWS | RESEARCHING THE GENOME'S 3D STRUCTURE
New study provides further understanding of chromosome reshuffling and how the organisational plan within the nucleus influences biological and disease processes.
where broken chromosome ends rejoin, knowledge that could shed light on fundamental processes related to cancer and normal cellular functions. The study, led by Frederick Alt, director of the
R
Program in Cellular and Molecular Medicine at Children's Hospital Boston and the IDI; and Job Dekker, codirector of the Program in Systems Biology at the University of Massachusetts Medical School, reported their results online in Cell. In cancer cells, the process of chromosome
rearrangement, or translocation often results in the creation of new cancer-promoting 'fusion' genes. Similarly, when a na“ ve B-cell starts to produce antibodies for the first time, it establishes its choice of target by breaking and recombining genes for antibody diversity. 'While chromosomal breaks and
translocations are fundamental to many cancers, historically we've had no approaches to systematically study how they are generated,' said Alt. 'About 5 years ago, our group set out to generate a high-throughput approach to address this important problem in cancer biology.' To accomplish this goal, the Alt lab developed high-throughput genome-wide translocation
sequencing (HTGTS) and at a level of resolution not previously thought possible. In early HTGTS studies, they found that broken chromosomes often rearrange within themselves, as opposed to sharing pieces across different chromosomes. To probe these findings more deeply, his
laboratory joined forces with Dekker's to combine HTGTS with a method called Hi-C. Developed by Dekker's group, Hi-C measures how all the sequences in the genome are organized relative to one another in three dimensions. The combined data revealed related but
distinct principles of how genomic organisation governs chromosome rearrangements.
Together, the principles highlight the relationship between proximity, genomic organisation, and break frequency. The new understanding of the roles of
physical spatial proximity and overall 3D genome structure in chromosomal translocations opens new avenues for deciphering how the way a cell's nucleus is organised affects the genomic disarray found in cancer and other diseases characterised by chromosome reshuffling. The study also shows the power of combining two high-throughput genomic assays ® Hi-C and HGTGS ® for studying how the organisational plan within the nucleus influences fundamental biological processes.
DASIL ANNOUNCES OFFICERS AND BOARD OF DIRECTORS
The Dermatologic & Aesthetic Surgery International League (DASIL), has proudly announced the election of Officers and appointment of the Board of Directors. The designations create an international leadership cadre encompassing the most talented dermatologic surgeons from around the world. Elected to Officer posts are:
President, Michael H. Gold, MD (USA); President Elect, Sheldon V. Pollack, MD (Canada); and Treasurer, Marc B. Röscher, MD (South Africa). 'I believe that we have assembled the finest collective group of
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dermatology and aesthetic professionals to lead DASIL,' said Dr Gold. 'The wealth of experience that our Officers and Board of Directors bring to this organisation ensures that members will consistently find value in our association through mentoring programmes, annual meetings, peer opportunities, and professional interface.' The Board of Directors spans an
international spectrum that highlights DASIL’s mission to be a worldwide professional organisation. DASIL is first and foremost a physician organisation, the key vision
March 2012 |
prime-journal.com
of which is to ensure that future leaders have values that are consistent and aligned with the mission of DASIL. Jose Mena, President of HTC
International, and serving as Managing Director of DASIL, said: 'We are thrilled to have the most respected dermatologic and aesthetic professionals on board with the mission of DASIL; and it is they who will help lay the foundation of this exciting organisation.' For further information, or to obtain a membership application, visit www.
theDASIL.org
ESEARCHERS HAVE DISCOVERED that where each of the genome's thousands of genes lie within the cell's nucleus
® i.e. the
genome's 3D organisation ® holds great influence over
Corrigendum
Carboxytherapy: Carbon Dioxide Injections in Aesthetic Medicine. PRIME 2012; 2(1): 42–51 An editorial error occured on page 48 of this article. The patient in Figure 7 was actually treated using Carbomed CDT Evolution, from Carbossiterapia Italiana Srl. For further information on this product, visit www.
carbossiterapia.it; stand E3 at AMWC Monaco.
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