GENOMICS
Predictor-intercept classification Rare diseases P
Gene therapies I
Teen mental health P Assess mental health I Adult major condition P Personalised plans I
Elderly multimorbidity P Review polypharmacy I Nutrient/pharma-omics P Lifelong targets I
Generative AI transparency in the real world with human phenotype ontology the primary care Address ethical and legal data use for ontology use case P I
Focus on design of proactive management by practitioner and citizen P I Coordinate multidisciplinary roles from development to adoption P I Semantic interoperability and traceability services for sector P I Integration knowhow of ecosystem data sources for HPO models P I Impact analysis of P
in relation to I is assessed for populace groups
Data driven decisions from PHM ecosystem to HPO models P I Risk stratification P
and segment disease groups I for effective PHM
Neighbourhood clinics engage and educate the public on outcomes P I Feedback loops, reinforcement learning and continuous improvement P I
Table 4. Real-world setting for predictors and intercept classifications. P – Predictors [Pre-eXams], I – Intercepts [eXams].
genomic testing pathway. (NHSE, 2025)
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10 Fuat A, Adlen E, Monane M, et al. A polygenic risk score added to a QRISK®2 cardiovascular disease risk calculator demonstrated robust clinical acceptance and clinical utility in the primary care setting. Eur J Prev Cardiol. 2024;31(6):716- 722. doi:10.1093/eurjpc/zwae004
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James A Henry, MSc Mol Path Research, MSc Biomedical Sciences, PhD Candidate by Publication.
James was invited by the United Nations to submit a Scientific Policy Brief. His research, appropriated by the NHSE workflow lead in 2014, aligns with ISO 15189:2022 Annex A and supports the global Agentic AI vision for population health. This article, adapted from his seventh manuscript in population health, represents a decade of inquiry and iterative refinement, centred on an Ethical People Ontology Plan to deliver truth at the point of need for 50% of the population by 2035. To safeguard the originality and integrity of this foundational work, the manuscript is designated ‘no licence’ on the OSF framework [doi:10.31219/
osf.io/cg84z_v1] pending engagement and funding to support his doctorate by publication.
James.henry19@outlook.com
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