GENOMICS
An Ethical People Ontology Plan with population health benefits
To harness the full benefits of genomic medicine requires the development of human phenotype ontology, to serve as a standardised, evolving language for describing individual biological profiles. Here, James Henry describes the three technical phases which enable the shift to data-driven proactive care.
The UK’s ambition to become a global leader in health innovation hinges on the ethical and equitable deployment of advanced technologies. This article outlines an ‘Ethical People Ontology Plan’ proposal in a foundational ecosystem for a new era of population health management (PHM). Forged from an alignment of four national strategic plans: the Genomics Medical Service Draft Specifications (Genomics England Plan); the Life Science Sector Plan; the NHS 10-Year Plan; and a new People Plan - this initiative uses an agentic AI-driven ecosystem to create biological Pre-Post eXams.
These phases enable a fundamental
shift from reactive to proactive care, powered by real-world data and federated quantum learning. By focusing on human phenotype ontology (HPO), this plan operationalises a clinical decision support (CDS) ecosystem that not only personalises medicine but stewards public trust, mitigates health inequalities, and cultivates a society prepared for the future of genomic health. Ultimately, the Ethical People Ontology Plan serves as the human-centric backbone for technological advancement, ensuring that a robust ethical framework, a skilled workforce, and an engaged public are
GLOBAL CLINICAL HEALTH IMPROVEMENTS STANDARD SCIENCE AND TECHNOLOGY
POPULATION HEALTH Genomic Health Prediction
The Pre-eXam
Genomic Medical Service Plan (2026)
PHENOTYPE ONTOLOGY Target Care Precisely
The eXams Life Science
Service Plan (2025) STEWARDING HIGH EXPERT MEDICAL SCIENCE SAFETY Fig 1. Aligning the population health management ecosystem. 48 SEPTEMBER 2025
WWW.PATHOLOGYINPRACTICE.COM
CONTINUOUS AGENTIC AI IMPROVEMENT
The Post-eXams
National Health Service 10-Year Plan (2035)
ETHICAL ONTOLOGY PEOPLE PLAN FOR TRUTH AT POINTS OF NEED
central to achieving population health benefits and a healthier, more equitable future for the UK.
Introduction This article represents the fourth in a series for Pathology in Practice and is forged from the seventh manuscript in the Frontiers Journal of Artificial Intelligence, Medicine and Public Health [Preprint available on OSF “No license”], titled ‘Align Four UK Plans in an Ecosystem for Agentic Pre-post eXam Predictors and Intercepts’. The UK is embarking on a transformative journey, strategically aligning four national plans1-4
to create
© copyright James Henry
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