NOVEMBER 2022 THE RIDER /11 as a Possible Future Treatment for Equine Asthma


tion with a biologic therapy like stem cells versus traditional drugs, like corticosteroids is clearly attractive. For administration of treatment, Bi- enzle explains there are already well-developed


Important Notice: Amendment To EC Rules


tions of the Equestrian Canada (EC) Rules have been amended through the Extraordinary Rule Amendment (ERA) process, effective immedi- ately:


Section G: Hunter, Jumper, Equitation and Hack Noteworthy updates and changes are out-


lined below. Section G: Hunter, Jumper, Equitation And Hack


process for the CET Medal National Final has been amended to include the method by which the top sixteen riders are selected should any re- gion not have four qualified entries. In the event that a qualified rider cannot compete, the next placed rider from the Regional Final Top 6 Ride- Off will be accepted. Should any region not have four qualified entries, the next qualified rider from the National Rankings will be accepted, up to 16 riders total. To be eligible for the National Final, riders must have competed in a Regional Final.


View the amendment summary View the complete rule book, Section G: Hunter, Jumper, Equitation and Hack For more information on the EC Rules, visit www.equestrian.ca/programs-services/rules.


Rules can be directed to: Lindsey Blakely


Questions? Comments? Questions and comments regarding the EC


343-308-4392, lblakely@equestrian.ca


Coordinator, Technical Programs - Officials and Rules


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Please be advised that the following sec-


of good hay, clean air and other important stable management considerations in a video interview where she goes on to explain the exciting new research investigating stem cells as a potential future treatment option. The potential to downregulate inflamma-


able to perform as athletic horses or even as a companion horse with a little bit more strenuous riding,” says Bienzle. “It’s an incurable disease for the most purposes. It’s somewhat treatable, but not curable.” Dr. Bienzle elaborates on the importance


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develop a ‘heaves line’ (hypertrophic abdominal muscles are recruited to assist with exhaling air). By the time equine asthma is diagnosed, it has usually been present for a few years, if not sev- eral. Treatment of the symptoms includes im- munosuppression, but the disease cannot be reversed. “The vast majority of the horses are un-


ticulates, the condition worsens, and the cough- ing becomes more continuous. The nose may be running and then there is thickening of the bronchial wall in the lung. There is extra smooth muscle being laid down and it becomes hard for the horse to exhale against mucus and inflamma- tory cells in the lumen of the airway. In the later stages of disease, horses can


heaves are long term exposure to dusty or mouldy hay, bedding, dusty environments and sometimes even grass in hot humid climates that provide the right conditions for mould to thrive. “Horses get sensitized to these components in the inhaled air and with time, they develop air- way inflammation and that begins to manifest with occasional coughing or runny nose.” With continued exposure to the same par-


leave a horse struggling to breathe, ending ath- letic careers and even rendering a pleasure horse unsuitable for riding. Commonly known today as equine asthma, it’s an irreversible disease brought on by repeated exposure to dust and moulds. Ontario Veterinary College researcher, Doctor Bienzle has a long history of primary and collaborative work studying asthma in horses. Her most recent contributions include working with a group of researchers in Slovenia, investi- gating stem cells as a potential treatment option. Bienzle explains the usual causes of


Heaves is known as a disease that can


ise required to produce stem cells, Bienzle says, “This is not for the casual investigator because it takes some experience to have the right culture con- ditions to make sure those cells are clean. They are not cultured for very long, and when the final


methods for examining the lower airway using en- doscopes. Administering stem cells using this tar- geted method may be an appealing option versus intravenously where it is uncertain where the treat- ment ends up. When explaining the challenges and expert-


tration of autologous adipose-derived mesenchymal stem cells on severe equine asthma, published in


quite exciting, with stem cell therapy outperform- ing traditional corticosteroids. Stem cells have no side effects per se, as many drugs do, which makes the study of biologic treatments very attractive. This study, Effect of intrabronchial adminis-


preparation is administered to an animal, it must be free of cell culture components that could make in- flammation worse.” The preliminary, proof of concept work is


Stem Cell Research and Therapy, was funded by the Slovenian Research Agency fund. The ground- breaking work is in its infancy with future studies planned which could one day help horses, and po- tentially humans suffering from asthma utilizing bi- ologic therapy. More tips on equine respiratory health avail-


Canadian Academy of Health Sciences for out- standing contributions in the field of research.


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able for download at Equine Guelph.ca Dr. Bienzle has recently been named to


Stem Cells Under Investigation


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