CHROMATOGRAPHY
GPC/SEC COMBINATION DETECTOR ANALYSIS T
esta Analytical has developed a new multiple
angle light scattering/ differential refractive index (MALS/DRI) combination detector package for more demanding gel permeation chromatography (GPC/SEC) applications. Delivering absolute molecular weight data from small to large molecules, MALS has established itself as a tried and trusted GPC/ SEC detection technique for polymer, protein and polysaccharide applications. However, the most accurate and sensitive results can be only achieved by pairing MALS with a DRI detector, designed to deliver concentration information detected at the very same wavelength.
to optimally operate using an integral 640nm light source. Fully compatible with
The new Combo-Two MALS/DRI
detector package brings together a perfectly matched combination of a high performance seven-angle MALS and an ultra-stable DRI detector - both designed
all commercial GPC/SEC systems, the Combo-Two offers what its maker claims is the lowest possible delay volume between the MALS and DRI detectors, enabling exceptional results to be routinely obtained. Operating from room temperature up to 80°C, with high thermal stability, the new system is simple to use – users just inject their sample into the low-volume flow cell to obtain highly accurate and
reliable MALS and DRI data. For more information visit
www.testa-analytical.com
CERTIFIED CONTAMINANT-FREE SAMPLE VIALS W
aters has announced a new test protocol for its LC/GC certified vials along with a new addition
to its line of TruView pH control LC/MS certified vials. The LC/GC certified vials undergo a new and highly-sensitive UPLC-UV certification test at 195nm at a contamination level of
<100 ppb to ensure that not just the sample vial – but its cap and septum too – are all free of contamination. Passing this test is sufficient to ensure contaminant-peak-free operation under typical LC-UV conditions. The new TruView pH control LC/MS
certified vials have a modified glass surface which limits the leaching of free sodium ions into solution. This limits a pH drift away from the neutral thus reducing unwanted chemical reactions and resulting ghost peaks. The vials also reduce analyte loss due to the adsorption of polar bases.
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www.scientistlive.com As much as laboratories try to eliminate
the risk of producing erroneous results, more than 50% of customers polled by Waters report occasional or even frequent problems with contamination or ghost peaks. These latest editions to the sample vial portfolio help eliminate vials as a cause of out-of-specification results. One happy customer is Dr Hartmut
Kagerer, head of quality control at Bayer. Kagerer comments: “Analyte degradation induced by pH changes in the sample vial and chromatographic ghost peaks have been a challenge in our workflow. The random appearance of unknown peaks has slowed our research efforts and challenged the quality of the results. We have been looking for a sample vial that limits the pH drift away from the neutral. Using a sample vial with controlled surface parameters and a high vial-to-vial reproducibility is transformative as it increases data quality and reduces uncertainties with result interpretation.”
For more information visit
www.waters.com
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