MICROPLATE READERS
NEW SYSTEM DELIVERS SUPERIOR ASSAY STABILITY S
teady experimental conditions are a prerequisite for
robust and high-quality data. Temperature is one factor that may signifi cantly aff ect experimental results, especially when screening assays in 384 or 1,536 well formats. If temperature fl uctuates when an assay or detection is in progress, changes in thermodynamic conditions can infl uence many events including molecular interactions, the effi ciency and kinetics of chemical and biochemical reactions and the photon yield of luminescence and AlphaScreen/AlphaLISA assays. This can result in irreproducible results, potential false positive signals and poor statistical outcomes. Many factors can infl uence the internal
operating temperature of a microplate reader. In a lab, room temperature can fl uctuate depending on location, exposure
within the instrument that generate heat, especially if the reader is heavily used. The new Advanced Assay
to sunlight, time of day, local climate, season, heat from neighbouring lab instrumentation and use of heating or air conditioning. In general, microplate readers can
control the internal temperature from a few degrees above room temperature to 45°C or higher. Typically, these instruments work to regulate the measurement chamber temperature. The gap between room temperature and the controllable temperature is mainly due to electronics
Stability (AAS) system enables the PheraStar FSX to match room temperature conditions and to be maintained at any temperature between 18 and 45°C. It achieves this by automatically heating or cooling the microplate measurement chamber depending on the external environment. The AAS system provides
a steady temperature that is unaff ected by external environmental changes while the plate reader is operating - providing improved assay stability and more reliable data. The special design of the AAS system, which is a closed system, also eliminates the external airfl ow to the inside of the plate reader and helps keep humidity constant.
For more information visit
www.bmglabtech.com
LATEST MULTIMODE PLATE READER LAUNCHED researchers to screen millions of samples
P
erkinElmer has launched the EnVision Nexus system, its fastest and most sensitive multimode
plate reader to date, designed for
demanding high-throughput screening (HTS) applications and to accelerate drug discovery eff orts. The EnVision Nexus platform, with complementary microplates and optimised reagents from PerkinElmer’s drug discovery reagents portfolio, including proprietary HTRF and AlphaLISA
technologies and latest reagent kits, provides researchers increased assay fl exibility.
The new
system features high-throughput, exceptionally fast
dual detectors, enabling 24
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with the increased accuracy, speed and sensitivity. For walkaway convenience, the system can be equipped with a plate stacker for 20 or 50 plates or can also be fully automated and integrated for 24/7 workfl ow-driven automation.
“We’re transforming drug discovery,
and it all begins in the lab where researchers can leverage multimode plate reader
technology such as the EnVision Nexus system to increase R&D productivity at nearly every stage of their process,” said PerkinElmer
senior vice president of Life Sciences Alan Fletcher. “By
focusing on workfl ow simplifi cation and
expanded assay capabilities in a state-of-the-art microplate reader, complemented by our optimised reagent technologies, our team has created an all-around high-performing system built for today and the future.” The solution’s design draws on the
company’s experience and success with its EnVision system, which it describes as being a workhorse in laboratories around the world for more than 20 years. Easy to setup, use and maintain, the new platform works across major detection technologies, including fl uorescence intensity, fl uorescence polarisation, absorbance, luminescence and time-resolved fl uorescence (TRF). This means a wide range of assays can be performed for diff erent applications all with one instrument.
For more information visit
www.perkinelmer.com
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