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LCMS system supports mass-based peptide purification The VERITY®


271 LCMS system from Gilson combines the power of High-Performance Liquid Chromatography (HPLC) with Mass Detection (MS) for


conditional fraction collection. Initial screening for peptide purification can be done using smaller columns for scouting, and then the LC optimised conditions can be scaled up, allowing researchers to target a specific peptide for purification. In addition, with UV-VIS detection, the optional single quad VERITY 1920 MS Detector with electrospray ionisation (ESI) or atmospheric pressure chemical ionisation (APCI) ion sources supports targeted fractions collection using selected ion monitoring (SIM) channels.


With a mass range of 10-2000 m/z, the VERITY 1920 MS helps you easily detect large molecules such as peptides and small proteins. Many biomolecules carry multiple charges with electrospray ionisation so that even proteins of several tens of kDa can be measured within the 2,000 m/z range. The method takes advantage of the software’s powerful conditional fraction collection feature, which simultaneously combines UVVIS signals and up to five MS channels to improve selectivity and purity.


The VERITY 271 LCMS system is the ideal solution for peptide purification and laboratories seeking effective MS detection to isolate pure compounds from synthetic and natural products from lab to pilot scale. It makes mass detection affordable and straightforward for any purification work.


The VERITY 271 LCMS system can be used to perform mass-based purification of target peptides from a mixture. The system is controlled using TRILUTION® post-run MS and UV spectral data.


More information online: ilmt.co/PL/5BD0 and ilmt.co/PL/EVXJ LC Software, which provides real-time and 62604pr@reply-direct.com New mass spectrometer delivers sensitivity and resilience


At ASMS 2024, SCIEX, a global leader in life science analytical technologies, launched the SCIEX 7500+ system, the newest mass spectrometer in the SCIEX quantitative portfolio, building upon a legacy of reliable, sensitive quantitation. While sensitivity is critical to solving the most impactful analytical challenges, scientists are under pressure to meet deadlines faster and to quantify increasingly various and complex sample types. The SCIEX 7500+ system delivers both sensitivity and resilience when scientists need it most.


The SCIEX 7500+ system offers increased resilience across a large suite of sample types and workflows, and improved user-serviceability. Mass Guard technology, a new proprietary feature, actively filters out potentially contaminating ions, reducing the risk and frequency of instrument contamination, and maintaining the highest sensitivity for up to twice as long compared to existing SCIEX technology, particularly when running complex matrices. The DJet+ assembly is fully removable, allowing front-end serviceability so customers can maximise system uptime. At 800 MRM per second, the SCIEX 7500+ system is the fastest SCIEX Triple Quad to date, increasing the scope for large quantitation panels that need to incorporate new compounds of interest, thereby improving overall lab productivity. The system is supported by new functionality in SCIEX OS, which allows users to track instrument performance and automate decision making, reducing the potential for failed batches and repeat measurements. Additionally, compatibility with dry roughing pumps can reduce electricity consumption by 24% relative to oil-sealed pumps.


“Over the years, we have worked with experts in the field and innovated various breakthrough quantitative solutions. We have seen demand increase for testing on more and more sample types at high sensitivity. The SCIEX 7500+ system meets these needs by ensuring the highest performance can be maintained for longer and across these increasingly complex matrices,” said Joe Fox, President at SCIEX.


More information online: ilmt.co/PL/Q6Gy 62749pr@reply-direct.com Essential guide to spectroscopy selection: FTIR vs Raman spectrometers


Anton Paar, a leading provider of high-quality laboratory instruments, offers two exceptional choices in spectroscopy: the Lyza 7000 FTIR Spectrometer and the Cora 5001 Raman Spectrometer. This guide is designed to help potential buyers understand the distinct advantages of each, helping them make an informed decision about which instrument best suits their needs.


Lyza 7000 from Anton Paar exemplifies the latest in FTIR technology. This benchtop FTIR spectrometer offers precision and versatility for analysing solids, liquids, and gases. Lyza 7000 stands out for its ability to provide rapid, reliable measurements in combination with user-friendly workflows on the intuitive touchscreen interface. Its design is robust and optimised for quality control, including easy integration with AP Connect lab software, enhancing data management and operational efficiency.


The FTIR technique is particularly favoured for its broad applicability in identifying organic and some inorganic materials by measuring their absorption of infrared light at different wavelengths. This method is excellent for identifying and characterising samples, making it ideal for comprehensive material verification and quality control.


Complementary to this, Anton Paar’s Cora 5001 Cora 5001 is a state-of-the-art benchtop Raman spectrometer that’s renowned for its precision and ease of use. Raman spectroscopy can identify chemical compounds through their molecular vibrations, making it invaluable for chemical and pharmaceutical labs. The


Cora 5001 excels in reproducibility due to its autofocus that finds the best Raman signal within seconds, and can then analyse samples directly through glass or plastic containers. Its minimal sample preparation and fast, accurate measurements make it a top choice for rapid substance identification.


Raman spectroscopy is suited for situations where minimal sample interaction is desired. It is especially useful in pharmaceutical, cosmetic, and forensic applications where clear, definitive substance characterisation is required without altering the sample state.


FTIR is highly-recommended for comprehensive analytical tasks that require detailed information and quality control for a wide array of sample types, including deeply-coloured and fluorescent samples. For many samples, established SOPs (e.g. ASTM standards) for IR spectroscopy are available.


Raman is best suited for rapid, non-invasive testing and precise substance identification, particularly in pharmaceutical and forensic settings. Samples can be measured through packaging, allowing the measurement of air and moisture sensitive materials. Cora 5001 includes a battery option for analysis in the field.


Understanding the operational strengths and contextual applications of Anton Paar’s Lyza 7000 and Cora 5001 can significantly enhance both the efficiency and effectiveness of laboratory work. More information online: ilmt.co/PL/wzqO and ilmt.co/PL/wzqO


62530pr@reply-direct.com Compact XRF spectrometer redefines elemental analysis


footprint, striking the perfect balance between precision and efficiency. Revolutionising elemental analysis, Revontium provides high-quality results comparable to larger floor-standing systems while significantly reducing costs and environmental impact.


Malvern Panalytical introduced Revontium, the world’s premier compact XRF spectrometer, at analytica Munich. This ground-breaking instrument offers powerful elemental analysis within a compact 0.4 m2


X-ray fluorescence (XRF) technology is renowned for its non-destructive elemental analysis capabilities. However, traditional floor-standing instruments come with high energy and maintenance costs. Revontium stands apart as the only compact XRF spectrometer delivering comparable data quality to larger systems, all within a significantly smaller footprint.


Revontium provides over 25% lower ownership costs compared to traditional XRF, AAS, and ICP instruments. Its streamlined design reduces the need for consumables and simplifies maintenance and sample preparation. Unlike traditional instruments, Revontium requires fewer consumables, no daily calibration, and operates in ambient conditions, making it an environmentally friendly and cost- effective solution.


Ideal for industries such as cement, mining & minerals, and pharmaceuticals, Revontium enables compliance with stringent environmental regulations and test methods. It opens new avenues for elemental analysis, serving as an alternative or complementary technique to existing methods like ICP and AAS.


Lieven Kempenaers, Product Manager XRF at Malvern Panalytical, commented: “Revontium delivers powerful elemental analysis in a compact format, offering ease of use, analytical rigor, and low ownership costs. Our team is committed to supporting customers in maximising the benefits of Revontium.”


Mark Fleiner, President of Malvern Panalytical, added: “Revontium expands our XRF instrument offering, providing users with optimal precision and efficiency. This ground-breaking instrument unlocks endless possibilities for elemental analysis across diverse industries.”


More information online: ilmt.co/PL/qn8b 62484pr@reply-direct.com


LAB ASIA - AUGUST 2024


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