22 Conclusions
The results of the experiments described here demonstrate the ISQ 7610 GC-MS system meets and exceeds the EPA Method 8270E requirements for the analysis of PAHs in environmental samples.
• Gaussian peak shape and chromatographic resolution were achieved in compliance to EPA Method 8270E
• The XLXR detector demonstrated exceptional dynamic range, spanning over 4 orders of magnitude, from 2.5 ppb to 20 ppm for the 19 PAHs, with AvRF %RSD<10% for each compound, thus removing the need for the preparation of two different calibration curves and speeding up the analysis workflow
• IDLs and MDLs were in the low pg on column range, even for spiked matrices
• The system was shown to be robust, as performances were unchanged in terms of sensitivity, peak shape, and DFTPP tuning check, after 136 injections and 52 hours of continuous work
• The ISQ 7610 GC-MS system with NeverVent technology allows for ion source cleaning and column replacement without breaking the vacuum, thus ensuring minimal instrument downtime and high sample throughput. Unproductive instrument time is eliminated so more tests can be performed on the system
References
1. Lammel, G. Polycyclic Aromatic Compounds in the Atmosphere – A Review Identifying Research Needs. Polycyclic Aromatic Compounds 2015, 35, 316–329.
2. US EPA Method 8270E: Semivolatile Organic Compounds by Gas Chromatography/Mass Spectrometry, Revision 6, June 2018.
3. Thermo Scientific Application Note 10718: A fast, robust method for routine determination of polycyclic aromatic hydrocarbon (PAHs) in drinking water by single quadrupole GC-MS. Michela Balsamo et al.
https://assets.thermofisher.com/TFS-Assets/CMD/Application-Notes/an-10718-gc- ms-pah-drinking-water-an10718-en.pdf
4. US EPA Method 3510: Separatory Funnel Liquid-Liquid Extraction, December 1996. 5. US EPA Method 3511 (SW-846): Organic Compounds in Water by Microextraction, Revision 1, 2014. 6. US EPA Method 3546: Microwave Extraction, February 2007.
7. Thermo Scientific Technical Note 10721: Routine, robust analysis of PAHs and PCBs in soil by single quadrupole GC-MS. Aaron Lamb et al.
https://assets.thermofisher.com/TFS-Assets/CMD/ Technical-Notes/tn-10721-gc-ms-pahs-pcbs-soil-tn10721-en.pdf
8. Thermo Scientific Technical Note 10499: Practical determination and validation of instrument detection limit of Thermo Fisher Scientific ISQ LT Single Quadrupole GC-MS. Richard Law, Tommaso Albertini.
https://assets.thermofisher.com/TFS-Assets/CMD/Technical-Notes/tn-10494- single-quadrupole-gc-ms-tn10494-en.pdf
9. US EPA: Definition and Procedure for the Determination of the Method Detection Limit, Revision 2, December 2016.
Learn more at
thermofisher.com
Figure A1. System suitability test results for DFTPP in the Chromleon Data System - Environmental Pack.
For the analysis of volatile organic compounds (VOCs) in water (AN-000305) or the analysis of VOCs in soil (AN-000377) using purge and trap coupled to single quadrupole GC-MS, please contact
CMD.APACMarketing@thermofisher.com
Read, Share and Comment on this Article, visit:
www.labmate-online.com/article Thermal Management for Mass Spec LC/GC
Do you require greater thermal management options to properly sustain your samples throughout the entire workflow process? Do you need the temperature that best suits your particular sample preparation requirements? MéCour offers design specific thermal solutions for virtually all of the ‘standard’ options available that integrate with CTC PAL instruments including, Hotels, tubes, vials, plates and valves. Create a thermal management system that fully integrates with your existing or future PAL system. Operating temperature range is -80°C to +250° with a +/-0.1°C consistent tolerance with highly reproducible results for any of the MéCour products you choose to support your application.
Thermal Hotels provide between 4 to 6 thermal nests as contained within this unit for short- or long-term incubation or storage requirements. The Hotel will accommodate plates, vials and small tubes.
A wide range of thermal units accommodate vials, tubes, plates, etc., or additional MéCour units control sample temperatures for the valves and tubes. Any of these units will integrate with the PAL cross rail or can be designed to stand alone for benchtop work.
All MéCour thermal units provide both heating and cooling within the same block. Simply adjust or pre-program system to produce the temperatures you demand throughput workflow without changing anything else. If you need to sustain samples below 4°C down to -80°C, MéCour integrates the MDAS unit to provide a constant blanket of dry air to the interior of the thermal unit to control and eliminate condensation.
Contact MéCour to discuss how your end results can be improved through constant reliable thermal controls that will maintain and manage your samples and workflow process to your specifications. Eliminate the concerns you deal with due to erratic and unreliable end results that waste valuable product and work time.
More information online:
ilmt.co/PL/VYm3 55402pr@reply-direct.com
Portable Quadrupole Analyser for Environmental Field Studies
The Hiden pQA portable gas analyser is a versatile mass spectrometer and offered with a range of interchangeable sampling inlets to suit a broad application range. MIMS inlets are offered for analysis of dissolved species in ground water, fermentation cultures, soil samples, and general applications where analysis of dissolved species in liquid sample is required.
The system is suited to gas analysis applications, where sample volume is small, and for environmental applications where detection of low concentration levels is required. The pQA system has a mass range of 200 amu and sub ppb detection levels. Extended mass range to 300amu is optional
The system is supplied in a Pelican® laboratory use.
case and can be powered by a 12 V supply for field use, battery and/or solar powered, or a 220 V supply for
Sampling inlet systems are offered for a broad application range including: Direct membrane inlet probe for immersion and/or insertion in liquid or sludge sample, soil core sampling for example; Recirculating probe for analysis of sample with continuous flow, extracted sea or estuary water for example; Flow through probe, low flow design for denitrification studies.
The system includes: Quadrupole mass spectrometer system from the RGA series with mass range options 200 amu; Mass spectrometer analyser manifold
and UHV pump set with a manually valved dissolved species probe with silicone rubber membrane; Ion Gauge and interlocks to provide protection for the mass spectrometer in case of over pressure; fast acting shut off valve between the dissolved species probe and mass spectrometer manifold to protect the mass spectrometer in case of membrane failure - the valve is interlocked with the integral UHV pressure gauge; supplied in a ruggedised Pelican case for usability in the field; can be powered by a 12 V supply, from a vehicle power outlet, for example as well as a standard power outlet for laboratory use; total weight is less than 40 kg.
More information online:
ilmt.co/PL/ZpJv 54035pr@reply-direct.com
LAB ASIA - APRIL 2022
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