10
Cogent Column Filters for HPLC Column Protection
Protect and extend the life of your expensive HPLC Columns with the economical MicroSolv™ Cogent Column Filters™.
These fi lters safeguard your columns from damage caused by undissolved sample and mobile phase particles and shredded pump seals. These easy-to-use fi lters are an essential piece of protecting your analytical and guard Columns up to 4,500 psi and are available in 0.5um and 2um pore sizes.
The fi lter’s hand-tightened, universal connection threads fi t all HPLC columns and pilot lengths and are easily removed and replaced when system
pressure starts to rise. Bring the column pressure to an atmospheric level, remove the ‘used’ fi lter, and simply replace with a new one. The instrument operator can now be assured that no particulates can damage their HPLC column and interfere with their chromatography.
More information online:
ilmt.co/PL/KBga 57420pr@reply-direct.com
New Method Development Solution: Software Support for Analytical HPLC Method Development and Optimisation
Shimadzu has announced the release of its ‘LabSolutions MD’ software for analytical HPLC method development. In addition to established ‘Method Scouting’ functionality that enables automated, quick and simple column and solvent screening, the new LabSolutions MD method development solution supports ‘Analytical Quality by Design’ (AQbD). With a multifactorial experimental design, only a limited amount of experimental data is required to create a defi ned design space.
Computer simulation and retention modelling within this design space allow for fast, statistically informed decisions on suitable,
robust separation conditions, while reducing the risk of human error. LabSolutions MD, in combination with the Shimadzu LabSolutions chromatography data system, provides data management, evaluation, and intuitive reporting, all in a LabSolutions database, ensuring data integrity.
More information online:
ilmt.co/PL/9Dlv 56986pr@reply-direct.com
Four New Products for Enhanced Pyrolysis Analysis
Frontier Laboratories Ltd has launched four new products around the Multishot Pyrolyzer EGA/PY-3030D, their state-of-the-art vertical furnace pyrolyser (for Py-GC/MS), equipped with a programmable ceramic heater, enabling, beside single shot pyrolysis, thermal desorption, heart cut and evolved gas analysis.
The Micro-Jet Cryo-Trap MJT-2030E is an excellent tool for energy effi cient rapid cooling and instant thermal desorption (TD-GC/MS). Trapping of low boiling compounds (CO2
, ethane, etc) is possible due to the liquid nitrogen jet fl ow and cooling temperature of -196ºC. It enables automatic heart cut analysis of gases evolved from Multishot Pyrolyzer. The Selective Sampler SS-2010E is provides Heart-Cutting of desired Peaks and comes with a new Flow Switching System.
Various atmosphere gases (He, Air, etc) can be used. The Multi-Functional Sampler MFS-2015E makes splitless Pyrolysis possible without compromises, enabling 100x improved sensitivity (with LOQs in pg range). The MFS shortens analysis time by backfl ushing, solvent venting is also possible. It is the ideal tool for trace analysis, such as µ- and nano-Plastics, and additives detection. The new Cryogenic Mill IQ MILL-2070 is easy to use and simple to operate. Fast and effi cient high-speed milling is enabled by 3D/8-fi gure crushing ball motion. It pulverises samples at highest uniformity, homogeneity, and reproducibility.
More information online:
ilmt.co/PL/QB5n 57135pr@reply-direct.com
UHPLC analysis of cyclic peptides under LC/MS compatible conditions
Cyclic peptides are characterised by polypeptide chains that are arranged in a cyclic ring structure. This structure offers various advantages over their linear counterparts: on the one hand cyclic peptides show a higher thermal stability and a higher resistance to digestion. On the other hand, their rigid structure results in a better biological activity since the binding to the target molecule is improved. All these characteristics turn them into highly valuable drug candidates.
Cyclic peptides have various applications; the peptides in this application note, polymyxin B sulphate, daptomycin and bacitracin are used as antibiotics for the treatment of bacterial infections, whereas cyclosporin A is used as an immunosuppressive agent. Other cyclic peptides can also have antifungal or antitumor functionalities.
In YMC’s application note ‘UHPLC separation using column of low hydrophobicity’, the UHPLC analysis of four cyclic peptides is shown. Based on the hydrophobicity of the peptides, a YMC-Triart Bio C4 column was chosen for this application. Since a relatively high concentration of acetonitrile is needed for elution, a C4 modifi cation is a good choice since it provides more acceptable retention times. Since a temperature of 70°C is required, YMC-Triart Bio C4 is a better column choice due to its high temperature stability. Sharp peaks are obtained with a mobile phase containing formic acid, which is commonly used for LC/MS analysis. YMC-Triart Bio C4 shows high sensitivity using these LC/MS compatible conditions.
More information online:
ilmt.co/PL/oXmB 57026pr@reply-direct.com
Streamlined Solutions for Natural Product Purifi cation
Since 1957, Gilson has been providing highly fl exible, reliable, and cost-effective solutions for science-based industries. Below is a selection of the most popular instruments making the highest contribution to your natural product purifi cation. Designed to integrate with your workfl ow, these systems set the standards for the industry and are complemented by worldwide service and support network.
The VERITY CPC Lab system combines a PLC Purifi cation System with a centrifugal partition chromatography (CPC) system for high-level target compound purifi cation. This automated, cost-effective, liquid-liquid purifi cation technique utilises reusable, silica-free chromatographic columns to streamline your workfl ow and allow you to isolate specifi c molecules with high yields and purity quickly.
The VERITY CPC Pilot system performs silica-free chromatography for pilot-scale purifi cation. This is the ideal CPC solution for annually processing milligrams up to multi-kilograms of natural product extracts with 95% recoveries and 99% purity or better. The system is a perfect fi t with Gilson LC purifi cation systems. For more effi cient pumping, the VERITY CPC Pilot system can be combined with a binary injection pump.
The VERITY CPC Process system performs silica-free (environmentally friendly) chromatography for industrial molecule purifi cation and extraction in pharmaceutical, cosmetic, food, and natural extract industries. This is the most advanced CPC solution for annually processing tons of natural product samples with the greatest returns for mainstream and minor cannabinoids. The system is designed to comply with the highest regulatory and safety standards (EU -UL, GMP -ISO, ATEX -HAZLOC) and allows maximised solvent recovery. The VERITY CPC Process system includes Gilson’s latest generation of LC SKID systems.
More information online:
ilmt.co/PL/y33R 56629pr@reply-direct.com
LAB ASIA - APRIL 2022
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52
