Chromatography 11 Optimised Refractive Index Detectors for HPLC and GPC/SEC


Testa Analytical Solutions eK reports on growing interest in OEM versions of its Differential Refractive Index (DRI) detector to enhance the performance of both HPLC and GPC/SEC systems.


Charlotte Stentzler, Technical Manager of Testa Analytical, said: “We have invested in stock components to enable us to offer our high performance DRI detectors, made here in Germany, on short delivery times. Being able to offer a wide range of options (light source, electronics, firmware) means these DRI detector can be readily adapted to fit the requirements of any third party HPLC or GPC/SEC system. Our DRI detector has been repeatedly shown to improve the accuracy and reliability of most chromatography systems when determining absolute concentration and total mass balance. Operating from room temperature up to 80°C with an outstanding thermal stability, the DRI detector also offers unsurpassed baseline stability and fast setting. Its sensitivity makes it the perfect RI detector to integrate into modern GPC/SEC and HPLC systems and to achieve peak performance even in the most challenging applications.”


She added: “The flexibility of our detector design has enabled us to supply OEM versions to suit a wide range of requirements ranging from low flow rate (down to 300 µL/min) as well as for standard HPLC and GPC/SEC applications. We are able to offer OEM supply agreements for the DRI detector starting at low yearly volumes, which makes it the perfect match for organisations focusing on supplying systems for niche chromatography applications.”


To discuss integrating an optimised version of the DRI detector into your GPC/SEC or HPLC system please contact Testa Analytical Solutions. More information online: ilmt.co/PL/pk2y


57175pr@reply-direct.com


GC Range Available at Affordable Monthly Payments


Ellutia Chromatography solutions can now offer a range of monthly payment options for UK customers looking to purchase a GC. Leasing or Hire Purchase means companies do not need to make a large capital outlay and could further benefit from potential tax savings. The already low entry price of the 200 series Gas Chromatograph combined with a range of funding options makes GC Analysis affordable to more laboratories without sacrificing analytical performance. Systems can be configured for manual injection or a range of autosampler options can be added.


The 200 Series Gas Chromatograph from Ellutia is a compact high-performance GC at an affordable price making gas chromatography accessible to every lab. Originally designed for use in education, the 200 Series GC is simple to operate with rugged construction making it the ideal first GC for scientists looking to start Gas Chromatography. The analytical performance however matches much larger costlier instruments from other manufacturers meaning it is just at home in a commercial lab as it is in the classroom.


More information online: ilmt.co/PL/Lq4w 56515pr@reply-direct.com


Robust and Reproducible Sample Preparation for LC/MS


Porvair Sciences has published an in-depth application report demonstrating how their Microlute®


CP Reverse Phase Solid


Phase Extraction (SPE) microplates provide a robust and highly reproducible SPE LC-MS sample preparation methodology for a range of neutral, acidic, and basic analytes.


As a sample preparation method, Solid Phase Extraction is widely acknowledged as a ‘go to’ tool for the clean-up of samples before analysis by hyphenated techniques such as LC/MS or GC/MS. Solid Phase Extraction offers several advantages to the analyst, including less system downtime and troubleshooting, cleaner chromatograms with a reduction of contaminating compounds, and greater reproducible analyte recoveries. Unfortunately, traditional SPE methods rely upon loose- filled resins which often create problems such as voids in the sorbent beds leading to channelling and inconsistent flow-through of solutions. These undesirable effects lead to reduced interactions between analytes and the active resin resulting in inconsistent results and poor analyte recovery.


Designed to overcome these shortfalls, Microlute® CP SPE microplates from Porvair


Sciences, incorporate a unique, polymer structure made up of an interconnected network of evenly distributed pores combined with retentive media. This hybrid technology ensures even liquid flow rates throughout the SPE process, which leads to sufficient time for Van der Waals forces of interaction to take place between the solid phase sorbent and the analytes resulting in a highly reproducible SPE method.


Experimental data is provided in the application report to show how Microlute® CP RP


96 well microplates selectively retain and elute a wide range of neutral, basic and acidic compounds. The data demonstrate how percentage relative standard deviation values from the Microlute®


CP are on average significantly lower than using other commercial


SPE plates, thereby producing more reproducible results. In addition, the application notedemonstrates that no analyte is lost in the load step of the SPE process leading to high recovery values for all types of compounds. The Microlute®


CP RP 96 well-plate


for solid phase extractions is also shown to offer significant benefits for the recovery of hydrophobic basic analytes.


Read the application report in full: ilmt.co/PL/9pKn More information online: ilmt.co/PL/6pw3


57154pr@reply-direct.com Not All Vials Are Created Equal


RSA™


Autosampler Vials for better chromatography data.


Only RSA™ l Prevent pH Changes


l Great for Bio-Active


Compounds Prevent hydrolysis in your vial due to glass with reduced surface silanols.


l Minimize Sample


Adsorption Insure quantitation precision run to run for low abundance basic compounds.


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Vials: l Prevent Adducts Seen


in the Vial Beware of ordinary borosilicate glass vials, they have variable surface chemistries.


in LCMS from the Vials Minimal surface metals.


l Cleanest Vials on the


Market Prevent spurious peaks from ordinary glass vials that contain residual manufacturing agents.


l Made with Superior


Dimensional Control Protect your sample needle and instruments.


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