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New Integrated Plug & Play Upstream Development Service
Merck has launched its Plug & Play Upstream Development Service to help emerging biotech and start-up companies optimise the cost and speed of advancing their molecule to the clinical stage. Eliminating the need to work with multiple vendors for upstream development, the new service reduces bottlenecks, lowering time to clinic by two months
The Plug & Play Upstream Development Service includes: Cell line development, utilising CHO cell lines or Merck’s proprietary CHOZN® analytics and early material from stable pools; Stability study and clone selection.
license; Standard
For customers looking to progress at an even faster speed, Merck offers its fast-track process by running process development and clone development steps in parallel, balancing speed and risk without sacrificing quality. The company’s robust and automated mini-pool approach allows it to more efficiently generate early material for process development, reducing the timeline by 10 weeks for the first pharmacodynamic experiment at the pre- clinical stage.
Customers are supported by a dedicated project manager and Merck expertise including risk assessment and regulatory expertise. Monoclonality and stability validation is fully documented based on regulatory expectations and a statistical approach. There are no royalty fees and customers have the freedom to technology transfer at any stage, to any partner.
Optional, add-on plug and play services are available, depending on customers’ needs, including: off-the-shelf media and feed screening; analytical method development; complete analytics; GMP master cell bank (MCB) and cell bank characterisation; MCB storage.
Customers also have the option for Merck’s BioReliance® Product Characterization team to synthesise data from multiple analytical and bioanalytical
methods to help reveal the true identity of the product, ensuring the biotherapy’s safety, purity and potency with off-the-shelf mAb-based assay packages or a custom assay tailored for the biologic. Based on the mAbs needs, the product characterisation team would recommend vital assays to provide all key physiochemical, binding and functional critical quality attributes and selects the lead clone for the generation of the desired product.
The Plug & Play Upstream Development Service demonstrates how Merck’s BioReliance® More information online:
ilmt.co/PL/MJZo End-to-End Solutions help companies realise their drug
development goals. With more than 32 years of experience and over 250 biomolecules, this group helps small-sized biotech companies and start-ups at all stages from molecule development towards commercialisation.
49789pr@reply-direct.com New Short Film Takes You on the Journey to Redefine the Kilogram
In an impressive act of cooperation, the General Conference of Weights and Measures member states voted to adopt a new kilogram definition for the first time since instituting the international prototype kilogram, or IPK, in 1889. This was the culmination of the years-long effort to create greater constancy in mass measurement examined in ‘Everything Different, Nothing Changes: Redefinition of the SI Unit Kilogram’, a new short video by Mettler Toledo.
At a basic level, all standards including mass are now tied to fundamental natural constants. In the case of mass, the referenced value is the Planck constant, also known as the fundamental constant of quantum physics.
In the 20-minute piece, Christian Müller-Schöll, Mettler Toledo, Dr Richard Davis, BIPM, and other metrology experts including Dr Philippe Richard, METAS, explore the science behind the definition, as well as the nearly poetic way the definition was able to be proven. This combination of smart thinking and technological excellence has produced measurement accuracy that is accessible for all people in all places at all times.
Rare footage takes you inside areas normally reserved for only a few metrology experts to witness everything from the highly technical Kibble balance used to calibrate reference artifacts to equipment used to create the enriched silicon sphere that was also part of the proof. These strong visuals help to make real the ongoing discussion around the kilogram, a discussion that can seem largely theoretical, especially to those accustomed to dealing with physical weights.
The new kilogram definition eliminates the need to rely on a physical object located in one place, providing a limitless and previously unimaginable access to mass-measurement accuracy. “We are pleased to have been part of the effort to make this new definition a reality,” said Mr Müller-Schöll.
To see a brief, exciting trailer for the video, please visit:
ilmt.co/PL/ZWWP To view “Everything Different, Nothing Changes” in its entirety, please visit:
ilmt.co/PL/QJDg
49675pr@reply-direct.com
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