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Monitoring Catalyst Concentration in Purified Terephthalic Acid Production
Purified Terephthalic Acid (PTA) is a white crystalline powder used as a precursor in the production of common plastics such as polyethylene terephthalate (PET) and polybutylene terephthalate (PBT). These materials are used in many different products, including polyester fibres, packaging, electronics and construction materials. Global production of PTA reached 61.2 million tons in 2016.
The production of PTA is a multi-step process involving hazardous and corrosive substances. The manufacturing process involves the oxidation of paraxylene in acetic acid. This process relies on a cobalt-manganese-bromide catalyst. The quantities of the catalyst must be carefully controlled to ensure high yields at high quality. Regular measurements of the catalyst concentration by X-ray fluorescence (XRF) analysis helps to monitor the reaction, ensuring just the right amount of catalyst is present in the solution.
Hitachi High-Tech’s X-Supreme8000 is a benchtop energy dispersive XRF analyser that can help you monitor your processes in PTA production. It’s simple to use, so can be operated by either laboratory or production staff. It provides rapid sample analysis with virtually no sample preparation. The X-Supreme8000 is the workhorse of many production facilities and is often in use 24/7.
You can test for the catalyst elements cobalt, manganese and bromine simultaneously. High precision, fast measurement times and low detection limits are achieved with a high-reliability tungsten target X-ray tube and a high-resolution silicon drift detector with optimised measurement parameters. The use of a Helium purge under the sample helps reduce the potential adverse effects of a corrosive atmosphere. The X-Supreme’s rugged design means it can be located right next to the production process, helping to keep production delays to a minimum.
More information online:
ilmt.co/PL/3Zkr 49718pr@reply-direct.com
New High-resolution Mass Spectrometry-based Workflow Simplifies Biopharmaceutical Characterisation and Quality Control
The Thermo Scientific™ HR Multi-Attribute Method (MAM) meets the demand for a single, high-resolution mass spectrometry-based workflow designed to directly assess the product quality attributes of increasingly complex biotherapeutics. The workflow replaces the complicated sequence of lower-resolution methods that have previously prolonged characterisation timelines. Supported by the Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) software, the HR MAM method simplifies and standardises biotherapeutic characterisation throughout the product pipeline, facilitating the transition of new drugs from initial research to development and manufacture.
With the launch of this new high-resolution mass spectrometry-based workflow, biopharmaceutical scientists are no longer restricted by the complex series of assays typically required for the characterisation and quality control of protein therapeutics.
The HR MAM provides biopharmaceutical scientists with: a supported, comprehensive workflow from sample analysis to data processing, including new peak detection; method development, SOP management and product quality attribute discovery capabilities through the integration of the Thermo Scientific™ BioPharma Finder software with Chromeleon CDS software; flexible, 21-CFR part
11 compliant Chromeleon CDS software that supports the transition of development programs from early research to manufacturing and testing; high-resolution accurate mass capabilities and quality data to accurately identify peptides and post-translational modifications and allow reliable new peak detection using the Thermo Scientific™ Q Exactive™ Plus mass spectrometer.
More information online:
ilmt.co/PL/zgJL Next-Generation 80 MHz Benchtop FT-NMR System Introduced
Bruker have announced the European launch of the Fourier 80 system, a next-generation, high-performance 80 MHz Fourier Transform nuclear magnetic resonance (FT-NMR) benchtop spectrometer. The Fourier 80 has been designed for organic or medicinal chemistry research, routine analysis, teaching or synthesis verification in any chemistry laboratory. Equipped with a novel, ultra-stable 80 MHz permanent magnet, it requires no cryogens, magnet power supply, water cooling or special laboratory infrastructure.
The Fourier 80 has been designed for highest data quality and stability at 80 MHz, with excellent lineshape, resolution and sensitivity in 80 MHz homonuclear 1H or heteronuclear 1H/13C FT-NMR experiments. It runs Bruker’s TopSpin™ software, giving users access to the extensive TopSpin library of 1D and 2D homonuclear and proton-carbon heteronuclear experiments and pulse programs. In addition, the Fourier 80 offers the new, easy-to-use GoScan™ software module for NMR novice users.
Building upon Bruker’s decades of experience in high-field FT-NMR, the Fourier delivers robust high performance in a compact and affordable benchtop system. The Fourier 80 makes NMR accessible in essentially any lab where chemists work. It can be installed on a bench or in a fume hood without the need for new infrastructure, with easy maintenance and minimal cost of ownership. Novice NMR users can use pre-defined GoScan experimental options, while experienced users or lab managers can use Bruker’s industry-standard TopSpin software to access additional acquisition parameters, or advanced processing options.
The Fourier 80 offers workflows and protocols for academic, pharma and industrial chemistry research, forensics and organic synthesis control. It can be incorporated into chemistry education to introduce studets to the power of FT-NMR. An optional teaching package with recommended experiments and spectra interpretation guidance is available.
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