12
The Ideal Stationary Phase for Biotherapeutic Applications
In biotherapeutics, main compounds and impurities need to be identified and purified using chromatography and the stationary phase material is a key aspect to succeed in producing active ingredients.
Kromasil is a high-performance chromatographic media based on state-of-the-art spherical silica manufactured for optimum symmetry, efficiency and selectivity. Its narrow particle size distribution and large surface coverage lets chromatographers work with a wide variety of samples, from low molecular weight substances to peptides and proteins. Kromasil silica is highly porous which leads to high loadability and better productivity when carrying out purification, improving the overall process economy.
Kromasil materials are produced in Sweden, where specific particle sizes can be sieved from the same production batch, therefore, the stationary phase has the same properties across the particle size range. Accordingly, scientists and engineers can use the same type of material for analysis and characterisation under UHPLC/HPLC conditions as well as in preparative chromatography from discovery to API manufacturing. This advantage that Kromasil offers, saves weeks and even months of manpower time in a project, improving the return on investment by potentially accelerating significantly time to market.
For samples that need to be separated, analysed and purified fast and with confidence, use Kromasil by Nouryon where products are available in slurry- packed columns for lab analysis and small-scale purification plus bulk material for active ingredient manufacturing.
More information online:
ilmt.co/PL/p3Wy
New Triple-Phase SPME Fibres and Arrows Quickly Extract Both Volatiles and Semivolatiles
Restek first launched solid phase microextraction (SPME) automated sample preparation fibres to reduce sample handling and solvent consumption in many industries, such as environmental, food, and clinical. Soon after came rugged Restek PAL SPME Arrows, a revolution in microextraction that combines exceptional robustness with faster extraction times and trace-level sensitivity. Now, both fibre and Arrow lines are being expanded, including the addition of a sought-after triple-phase offering.
Of significant interest to many analysts, new triple-phase SPME fibres and Arrows provide exceptional versatility. This divinylbenzene (DVB)/carbon wide range (WR)/polydimethylsiloxane (PDMS) combination can be used for quick and efficient extraction of a wide range of both volatiles and semivolatiles, and it is an excellent choice for decision-making during method development because it combines the characteristics of three popular phases.
More information online:
ilmt.co/PL/AR0j Safe Columns for SFC
Robust YMC-Triart columns are the ideal choice for SFC. They are available from YMC with different selectivities (Diol, PFP, C18, Hybrid-Silica), particle sizes (1.9/3/5 µm) and dimensions. YMC-Triart columns cover the full range of applications from analytical to (semi)preparative scale. Full SFC compatibility and safety has been officially certified by the independent AFIN-TS institute (Analytisches Forschungsinstitut für Non-Target Screening GmbH). The well-known YMC reproducibility also comes with its renowned outstanding stability and reliability.
More information online:
ilmt.co/PL/xeVM 49154pr@reply-direct.com Fatty Acid Profiling of Oils
Olive oil is a very valuable commodity, which in some circumstances has led to the illicit practice of adulteration with cheaper oils (e.g hazelnut or sunflower oil). To combat this, a method known as FAME profiling can be used for oil identification. FAME profiling is the process of analysing the ratios of individual fatty acids within an oil sample. It works on the basis that different oils contain primarily different ratios of fatty acid types. To allow for analysis, the oils must first be derived to their fatty acid methyl ester equivalent (FAME).
This allows manufacturers and wholesalers the ability to confirm the authenticity of the products being bought and sold.
The Ellutia 200 series Gas Chromatograph (GC) is an ideal instrument for this analysis. The 200 series GC comes with a split split-less injector, fully temperature programable oven, electronic carrier gas control, and a flame ionisation detector as standard. The compact size (16(H) x 41(W) x 34(D) cm) and lower purchase cost makes it ideal of all sizes of budgets and laboratories.
For more information, a detailed application note has been produced. More information online:
ilmt.co/PL/GvJG
48043pr@reply-direct.com
49683pr@reply-direct.com
49539pr@reply-direct.com
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114 |
Page 115 |
Page 116 |
Page 117 |
Page 118 |
Page 119 |
Page 120 |
Page 121 |
Page 122 |
Page 123 |
Page 124
