MASS SPECTROMETRY & SPECTROSCOPY


High-precision synthetic sediment standard for IRMS and TOC


Elemental Microanalysis, a global leader in elemental analysis supplies, has introduced the first in a new series of synthetic sediment standards designed for isotope ratio mass spectrometry (IRMS) and total organic carbon (TOC) analysis.


The new reference material, B2251, replicates the elemental composition of natural sediment using carefully selected mineral and chemical ingredients. This synthetic approach allows for precise tailoring to match specific matrix


requirements, offering researchers a closer fit for their analytical needs.


B2251 is a high-organic-content sediment standard certified for TOC, total carbon, nitrogen, and sulphur. Elemental?s R&D team plans to expand the range during 2025, developing additional synthetic standards to support studies on carbonate removal techniques and to simulate the IRMS behaviour of previously sourced natural soils and sediments.


Synthetic standards offer key advantages over


Standards


natural equivalents: greater batch-to-batch consistency, fewer regulatory hurdles, and simplified global shipping thanks to the absence of export controls linked to irradiated natural soil.


Elemental Microanalysis also supplies a broad selection of synthetic soil standards certified for carbon, nitrogen, and sulphur content.


More information online: https://ilmt.co/PL/O546


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CDMS


Charge detection MS accelerates biotherapeutic analysis


ADVERTORIAL


Circular Dichroism beyond single-point checks: First accredited ISO 17025 CRMs deliver spectrum-wide confidence


Circular Dichroism (CD) spectroscopy is central to structural biology and chiral analysis. However, in 2025, many laboratories still rely on camphor-10-sulfonic acid (CSA) or ammonium camphorsulfonate (ACS) for instrument verification. These traditional methods require fresh preparation, are prone to hygroscopic error, and only validate a single peak near 290 nm. The result: The visible range goes untested, and compliance is left exposed.


Analysing today’s increasingly large and heterogeneous biotherapeutics remains a major challenge for drug developers, particularly in areas such as cell and gene therapy, mRNA, and complex protein assemblies.


Waters Corporation has introduced the Xevo™ Charge Detection Mass Spectrometer (CDMS) to address this gap, enabling direct, individual-particle mass measurement for biomolecules exceeding 150 MDa. The system allows accurate characterisation of protein complexes, nucleic acids, lipid nanoparticles, and viral vectors that are difficult or impossible to analyse using conventional techniques.


The Xevo CDMS can distinguish between empty, partial, full, and overfull viral vector capsids in less than 10 minutes per sample, while using up to 100-fold less material than existing methods. By removing the need for deconvolution or digestion, the approach delivers faster, more confident analysis across discovery, process development, and early manufacturing workflows.


“Advanced analytical tools are essential for understanding complex drug modalities earlier in development,” said Udit Batra, PhD, President and CEO of Waters Corporation. “The Xevo CDMS enables precise measurement of molecules that were previously beyond reach, supporting faster progress toward next-generation therapies.”


Powered by GxP-ready waters_connect™ software, the Xevo CDMS is available to order now.


More information online: ilmt.co/PL/OmvX 66532pr@reply-direct.com


Starna leads the industry with its Certified Reference Materials (CRMs) for CD. Each set contains permanently flame-sealed quartz cells – Blank, R,R, and S,S enantiomers – spanning both UV and visible regions (190–700 nm and 400–700 nm). Ready-to- use, these references eliminate weighing and waiting, removing preparation variability and ensuring reproducibility across instruments and locations.


Certification extends beyond static tables. Every set features a continuous Δε(λ) model and U95 uncertainty envelopes, so users can verify performance at any wavelength with


confidence. For those who prefer a rapid check, certificates highlight key maxima and minima: anchor points at 210, 237, 274, and 545 nm for UV, and 446, 479, 545, and 605 nm for VIS. Spot-checking instrument performance becomes straightforward, with no need for complex calculations. Certificates are valid for two years, offering lasting assurance between renewals.


As the first and only producer with an accredited (UKAS) scope for CD CRMs, Starna combines ISO 17034 production and ISO/IEC 17025 calibration for unmatched traceability and compliance. This achievement ensures every set is certified with globally recognised traceability for audit-ready documentation and spectrum- wide reliability.


For regulated environments, the advantages are clear: objective acceptance criteria, reduced operational risk, and data integrity you can defend. Say goodbye to stresses that result from last-minute scrambling to prepare unstable CSA solutions, or worrying about gaps in instrument calibration. With


Starna UKAS-accredited CD spectroscopy standards, you can demonstrate compliance and reproducibility across the full spectrum.


Ready to move beyond single-point checks? Request a certificate sample or technical briefing today to experience how Starna Certified Reference Materials can transform your laboratory’s approach to CD instrument qualification.


More information online: ilmt.co/PL/LwWd 65529pr@reply-direct.com


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