International


CONNECTING SCIENCE, BRIDGING INNOVATION


Triple quadrupole MS accelerates high-throughput analysis


speed, robustness and day-to-day reliability across biopharma, clinical translational research, environmental monitoring and food safety testing.


The TSQ Certis™ triple quadrupole mass spectrometer introduces a hardware and software package aimed squarely at one of the biggest demands in routine quantitative workflows: keeping instruments running for longer, with minimal downtime, while still generating confident, reproducible data.


A next-generation triple quadrupole mass spectrometer from Thermo Fisher Scientific, designed for busy, results-driven laboratories, has been launched, offering major gains in


Engineered for sustained, uninterrupted throughput, the system has been stress-tested to withstand more than 10,000 injections without cleaning, helping laboratories maintain productivity over long analytical runs. This ruggedness is combined with enhanced ionisation performance through an upgraded OptaMax™ Plus ion source, allowing sensitive detection of trace-level contaminants and accurate quantification of demanding analytes, including complex therapeutic peptides such


New software upgrade streamlines MS, NMR and chromatography workflows


Researchers working across NMR, mass spectrometry, chromatography, and predictive modelling are set to benefit from a broad upgrade to ACD/Labs’ Spectrus and Percepta platforms, released in their 2025 versions.


The latest Spectrus applications focus on something every analytical lab struggles with: getting instrument data into a format that is standardised, searchable, and usable across an entire R&D workflow. The update brings deeper hardware and software integrations, expanded import/export formats, and more powerful automation tools designed to reduce manual data handling.


A major focus of the release is low- code/no-code workflow automation. Improvements to Spectrus Conduit allow scientists to build and extend automated data-processing pipelines without vendor intervention. New bi-directional links between Katalyst D2D and Revvity’s Signals Notebook, plus the ability to attach Spectrus records directly within Luminata, are designed to cut down transcription steps and improve data accuracy.


Spectrus also extends its long-standing strength in native data import. Version 2025 adds the ability to bring in assigned 1D/2D NMR in JCAMP, JSON TetraScience for Empower, and improved MS and chromatographic formats. Expanded JSON and structure export options aim to


LIMS as GLP-1 analogues.


For laboratories handling rising sample numbers, the TSQ Certis MS also delivers significant speed improvements. The instrument can acquire over 900 SRM transitions per second, supporting large targeted quantitation panels without compromising data quality. Built-in predictive monitoring tools provide early notice of service needs, helping labs avoid unexpected interruptions.


Ease of use has been emphasised throughout the platform. Method templates and guided workflows mean both new and experienced users can achieve consistent results quickly, while direct integration with Chromeleon™ Chromatography Data System ensures secure, compliant data handling and enterprise-scale instrument management.


Pushkin Pant, Vice President and General Manager of Life Sciences Mass Spectrometry, Chromatography and Mass Spectrometry at


Mass Spectrometry


Thermo Fisher Scientific, said the system was designed to help routine laboratories work with greater confidence. “The TSQ Certis MS supports analytical scientists tackling challenges such as detecting trace contaminants in food or measuring increasingly complex biotherapeutics,” he said. “By combining robust hardware, predictive maintenance and compliance-ready software, we’re aiming to help labs focus their time where it matters most.”


The TSQ Certis MS is aimed at analytical scientists and lab managers across biopharmaceutical development, clinical and translational research, environmental testing and food safety, where reliable uptime, consistent quantitation and scalable data compliance are essential.


More information online: ilmt.co/PL/KMqV 66273pr@reply-direct.com


make data far more interoperable - a key requirement for labs feeding machine- learning or AI-driven pipelines.


For day-to-day analytical interpretation, scientists gain more control over processing parameters, enhanced peptide fragmentation tools, and clearer labelling options for mass spectral and chromatographic data. Reporting has been refreshed for faster documentation and better communication of results. The platform can now integrate selected third-party AI tools for reaction screening and optimisation.


Meanwhile, Percepta sees improvements in predictive accuracy thanks to expanded training sets. Improvements apply to solubility, logP (and its impact on pH-dependent logD), and cardiotoxicity models - supporting early- stage decision-making in medicinal chemistry and ADME/tox workflows.


Andrew Anderson, Vice President of Innovation & Informatics Strategy at ACD/Labs, said the update advances how organisations use analytical data: “We’re strengthening scientists’ ability to interrogate and share their data, and helping organisations assemble information in an AI-ready format. These developments are about enabling digital R&D in a practical, usable way.”


More information online: ilmt.co/PL/b8GY 66257pr@reply-direct.com


Advanced SIMS detector strengthens analysis of flexible solar cell materials


Hiden Analytical has introduced the Dual Polarity Simultaneous Detector for its SIMS Workstation platform, enabling more efficient and information-rich analysis of advanced materials used in flexible solar cells and other thin-film technologies.


Secondary Ion Mass Spectrometry (SIMS) is widely valued for its ability to deliver extremely high sensitivity and precise depth profiling, making it a core technique in semiconductor fabrication, thin-film coating, and materials research. By sputtering the sample surface with a controlled ion beam, SIMS reveals elemental and isotopic composition with resolution approaching individual atomic layers.


A longstanding limitation of SIMS analysis is the need to perform separate measurements for positively and negatively charged secondary ions. This not only increases analysis time but can also complicate the interpretation of complex, multi-layered samples.


Hiden Analytical’s Dual Polarity Simultaneous Detector addresses this challenge by capturing both ion polarities during a single analytical run. The result is faster data acquisition alongside improved alignment between datasets, delivering a more complete chemical picture without the need for repeat measurements.


MS


This capability is particularly valuable when analysing sophisticated photovoltaic structures such as CIGS-based flexible solar cells, where performance depends on subtle compositional changes across thin layers. In failure analysis scenarios, the ability to interrogate a single defect using both ion polarities in one measurement provides deeper insight into material behaviour and degradation mechanisms.


According to Dr Graham Cooke, Principal Scientist at Hiden Analytical, the new detector enhances the practical efficiency of SIMS while expanding its analytical reach, reinforcing its role as a powerful yet cost- effective tool for thin-film characterisation.


More information online: ilmt.co/PL/RnNv 66489pr@reply-direct.com


Laser Spectrometry Ion source technology sharpens view of the carbon nucleus


Measuring the size of an atomic nucleus is anything but straightforward. Now, researchers in Germany have achieved the most precise measurement yet of the carbon-13 nucleus, using laser spectroscopy supported by a high-performance ion source developed by Dreebit GmbH.


The work, led by scientists at the Technical University of Darmstadt, determined the root-mean-square charge radius of the carbon-13 nucleus to be approximately 2.46 femtometres, with an uncertainty of just a few thousandths of a femtometre. This represents a sixfold improvement in precision over earlier


electron-scattering measurements and sets a new benchmark for nuclear size determination.


The experiments were carried out at the university’s COALA facility (Collinear Apparatus for Laser Spectroscopy and Applied Sciences), where laser light was used to probe highly charged carbon ions. By analysing minute shifts in the emitted light, the team was able to map how positive charge is distributed within the nucleus — a key parameter for testing nuclear structure theories.


Central to the study was the Dresden EBIS-A electron beam ion source from Dreebit,


which supplied a stable, high-purity beam of carbon-13 ions in the exact charge state required for spectroscopy. The system is capable of producing highly charged ions across almost the entire periodic table, making it well suited to precision spectroscopy experiments.


Carbon-13 is particularly attractive for nuclear studies due to its well-defined structure and widespread use as a tracer. Building on this success, the researchers now plan to extend the technique to radioactive carbon-14. Although far more challenging to work with, carbon-14 measurements could dramatically


improve understanding of its nuclear structure and expand laser spectroscopy methods into the study of unstable isotopes.


“We are delighted that our ion source played a role in enabling such high-precision measurements,” said Lars Großmann, Managing Director of Dreebit. “This work shows how advanced ion beam technology can support fundamental spectroscopy experiments that push the limits of what can be measured.”


More information online: ilmt.co/PL/pmXM 66648pr@reply-direct.com


14


INTERNATIONAL LABMATE - FEBRUARY 2026


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