5
suitability for LNP production monitoring applications. Its non-invasive inline installation capability provides real-time measurement without disrupting fl ow patterns, while its broad solvent compatibility addresses the diverse buffer and solvent requirements in LNP production. Additionally, the dedicated fl owmeter software which is compatible with many Chromatography Data Systems (CDS) ensures reliable data collection and traceability. Overall, the implementation of this system enhances LNP formulation production reliability and regulatory compliance, which altogether results in reduced operational costs.
Conclusion
This study demonstrates that Testa Analytical preparative thermal fl owmeters provide superior measurement capabilities compared to traditional high-pressure monitoring approaches. The fl ow measurement approach presented minimises the possibility of costly process revalidation while achieving reproducible, scalable, and audit-ready LNP production. This methodology addresses fundamental challenges in process parameter control, system reliability, and regulatory compliance.
References
1.Roces CB, Lou G, Jain N, Abraham S, Thomas A, Halbert GW, Perrie Y. Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfl uidics. Pharmaceutics. 2020 Nov 15;12(11):1095.
Figure 4: Comparison of fl owmeter readings in Experiments 1 and 2. Each point shows a pair of simultaneous readings.
In this study, the Testa Analytical preparative thermal fl owmeter demonstrated its The Authors:
Hizkia Chandra is a product specialist, and Carlo Dessy the Managing Director of Testa Analytical. They may be contacted via
https://www.testa-analytical.com/
contact.html or +49-30-864-24076.
Read, Share and Comment on this Article, visit:
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