Drug Discovery, Pharmaceuticals & Cannabis Testing
Summary
With the Rapid Small-Scale Oxidation Test, the RapidOxy 100 offers a quick, easy, and reliable method to investigate formulas and products containing cannabinoids with regards to oxidation stability and product quality. The unique measuring principle leads to a signifi cantly reduced measuring time for the described investigations. Additionally, the straightforward principle gives rise to many further possibilities to access the oxidative behaviour of samples. By evaluating the pressure/time curve with OxyLogger 100 further, you can conduct automatic calculations of consumption, activation energy, and much more. Major benefi ts are its ease of use and fully automatic measurements. Since weighing in the sample is the only manual step, you minimise error sources as well. Independent from sample consistency, no sample preparation is necessary prior to the measurement. Therefore, you can investigate the oxidative behaviour of a sample as a whole.
References 1. Difonzo G., et al. 2018. Food Research International, 108: 48–56.
2. Guitard, R., Nardello-Rataj, V.*, Aubry*, J.M. 2016. International Journal of Molecular Science, 17: 1220.
3, H82IA016EN-A (Chia Seed Oil)
https://www.anton-paar.com/corp-en/services-support/ document-fi nder/application-reports/oxidation-stability-of-chia-seeds/
4. Edinger, C. 2023, Oils and Fats International, 39: 40.
5. H82IA008EN-A (Cocoa Mass)
https://www.anton-paar.com/corp-en/services-support/ document-fi nder/application-reports/oxidation-stability-of-cocoa-mass-and-vanilla-extracts/
6. XPAIA136EN-A (Food Powder)
https://www.anton-paar.com/corp-en/services-support/ document-fi nder/application-reports/ebook-mfi -food-powders-fi eld-guide-to-food-powder- characterization/
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www.labmate-online.com Scalable fl ow method produces enantiomerically pure pharmaceutical intermediates
Researchers at Lilly SA have pioneered a ground-breaking continuous flow method for the Wadsworth–Emmons cyclopropanation of alkyl-substituted chiral epoxides into chiral cyclopropane carboxylic acids, as reported by Uniqsis.
Utilising a custom setup comprising the FlowSyn continuous flow reactor and binary pump, the researchers successfully devised a novel flow process that overcame challenges associated with high temperature, pressure, and the volatile nature of the epoxide starting material.
The FlowSyn flow reactor demonstrated heightened efficiency by maintaining a higher concentration of low-boiling-point reactants in the liquid phase, due to its reduced headspace, resulting in enhanced reactivity compared to batch methods employing sealed vessels.
Furthermore, the researchers integrated their cyclopropane formation process with in-line workup and hydrolysis transformations, yielding enantiomerically pure cyclopropane carboxylic acids in impressive yields of up to 100 grams.
Uniqsis’s FlowSyn, designed by a team of experienced flow chemists and engineers, stands as a fully integrated continuous flow reactor solution. Offering seamless reaction optimization and scale-up capabilities from milligrams to hundreds of grams, FlowSyn serves as a versatile tool for pharmaceutical intermediates production.
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Optimise lab-scale purifi cation with benchtop nutsche fi lter dryers
Pope Scientific leads the way in laboratory separation equipment with its proven Benchtop Nutsche Filter Dryers. These compact units have been a staple in laboratories for years, offering researchers a powerful tool for testing, piloting, and small-scale processing. Pharma, fine chemicals, cannabinoids, electronics, and specialty materials are just a few of the many applications.
Pope’s fully enclosed sanitary design provides numerous advantages over traditional, open Buchner funnel apparatus. Materials are contained and isolated from the user for maintenance of purity and safety. Featuring ASME-certified pressurisability, filtering and cake washing is faster than via vacuum. Drying of the solids is also performed in the nutsche, efficiently accomplished under vacuum and jacket heating, plus a raising/lowering cake agitator to break up lumps and churn the solids. This is the same operation as industrial nutsches, but smaller.
Pope’s Benchtop Nutsche Filter Dryers are stocked in 1, 3, 4, and 5-litre sizes. All come pre-tested and pre-fitted with essential components including valves, sight glasses, pressure relief, spray assembly, pressure/vacuum gauge, and a manual with full documentation package.
In addition to stocked units, Pope specialises in custom designed lab, pilot, and production nutsches in a wide range of sizes, features, and functionality, and are optimised to meet clients’ processing needs and preferences. Pope Scientific has your solution – get in touch today.
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