Contents Head Office
International Labmate Ltd. Oak Court, Sandridge Park, Porters Wood, St Albans, Herts AL3 6PH, UK Tel: +44 (0)1727 855574 Fax: +44 (0)1727 841694
info@chromatographytoday.com
www.chromatographytoday.com
Michael Pattison, Chairman International Labmate Ltd.
Trevor Hopkins, Editor Chromatography Today Tel: +44 (0)7921 021378
trevor@intlabmate.com
Sales and Marketing Chris Jarvis, John Hobbs-Morris International Labmate Sales Team Tel: +44 (0)1727 855574
chris@intlabmate.com
john@intlabmate.com
Carol A. Hardy
North American Area Manager Tel: +44 (0)623 869 0184
Carol@intlabmate.com
Editorial Review Board Professor Tony Edge R&D Manager
Agilent Technologies, United Kingdom Dr James P. Grinias
Assistant Professor of Chemistry & Biochemistry at Rowan University, Glassboro, New Jersey, United States
Dr Jonathan Crowther Senior Research Fellow
Ortho Clinical Diagnostics, United States Dr Frank P. DiSanzo
ExxonMobil Research & Engineering Analytical Science Laboratory, United States
Ray T. McClain
Associate Principal Scientist Merck & Co. , Inc., United States
Dr Lucie Nováková Associate Professor
Charles University, Faculty of Pharmacy, Hradec Králové, Czech Republic
Dr Matthew Przybyciel
Vice President and Technical Director ES Industries, United States
Professor Torgny Fornstedt Analytical Chemistry
Department of Engineering and Chemical Sciences Karlstad University, Sweden
Dr Richard Henry Consultant, United States
Dr Gerard Rozing Consultant
Rozing.com, Germany
Dr Andrew Alpert President
Poly LC. United States Dr Martina Catani
Research Associate, University of Ferrara, Italy Production Team
Production Manager: Robert Battell
robert@intlabmate.com
Artworker: Jillian Mitchell
jill@intlabmate.com
Artworker: Heather Vincent Browne
heather@envirotechpubs.com
Production Editor: Gwyneth Astles
gwyneth@intlabmate.com
Chromatography Today is published with the full support of
Published – February/March, May/June, August/September and November/December
Chromatography Today is distributed free of charge to scientists, laboratory technicians and environmentalists throughout the United Kingdom. The publication has the support of leading suppliers of equipment in the region and is displayed at the major exhibitions and conferences in these markets to attract additional readership.
If you are not receiving your own copy of Chromatography Today please send us an email with your details to
info@intlabmate.com. If you are based outside of the United Kingdom a subscription charge of £55.00, €71.00 or $105.00 would apply.
Although every effort is made to ensure the accuracy of the material published, International Labmate Ltd and its offices cannot accept responsibility for claims made by contributors, manufacturers or advertisers.
© All rights reserved by International Labmate Ltd reproduction in part of whole without written permission is strictly prohibited
Published by International Labmate Ltd. Printed in the UK by The Manson Group Ltd
IBC Separation Science / Spectroscopy Meetings Calender
55 Workflow solution for antidoping analysis including steroids in urine
with GC-QqQ and GC-HRAM
38 Development of a novel combined IEX-RP chromatographic process
for the purification of bivalirudin ADVERTORIAL
44 Monitoring drugs in sport testing: an insight of current trends and recent
findings from the Drug Control Centre, the UK’s Anti-Doping Laboratory
50 A Marker-based Method to Detect Phosphorothioated Oligonucleotides in
Equine Plasma Using Spectroscopic Analysis
34 Gradient HPLC-UV Method for Cannabinoid Profiling
30 Increasing HPLC / UHPLC Sample Throughput: Doing More in Less Time
24 HILIC Flash Purification – Separation of Polar
Pharmaceuticals on Silica ISSN: 1752-8070
2 Foreword by Trevor Hopkins Articles
4 The Quest for True Ultra High Performance Supercritical Fluid Chromatography: a Mini-Review
10 Walk-up SFC-MS for Fast Purification of reaction Mixtures
within Discovery Chemistry
14 SFC-MS versus LC-MS - advantages and challenges
1
18 Gradient Retention Time Prediction for 653 Pesticides on a Biphenyl lc
Column Using Machine Learning
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68
