Infection Control & Hospital Epidemiology


Table 2. Estimates for Model Parameters of a Hypothetical Cohort of 30-Year Old Healthcare Workers (HCWs) Parameters


Base Case


HCW at entry, year 1 Workforce characteristics Total number of HCWs eligible for screening Proportion of new HCWs


Proportion of international HCWs


Proportion of HCWs working in high-risk ward Retention rate


Annual probability Prevalence of LTBI International Singaporean High-risk Low-risk


Prevalence of active TB International Singaporean


HCW from year 2 onward Annual probability Develop active TB High-risk Low-risk


Develop LTBI High-risk Low-risk


LTBI not cured after INH treatment INH treatment accepted by HCW INH-induced hepatitis


Hepatitis resolved after INH treatment Adherence with screening


Cost, per person (USD) Screening program QFT-G


6-month INH


Treatment of INH-induced hepatitis Treatment of active TB Discount rate, %


QOL (QALY) During 6-month INH treatment INH-induced hepatitis


During treatment of active TB Discount rate, %


Sensitivity Range


345


References


5,000 0.10 0.50 0.20 0.90


4,000–6,000 0.05–0.20 0.40–0.80 0.10–0.30 0.80–1.00


NUH NUH


NUH NUH


0.63 0.24 0.30 0.04


0.00089 0.00040


0.33–0.79 0.04–0.46


0.225–0.375 0.03–0.05


0.00067–0.00395 0.00035–0.00045


Menzies et al, 200720 Menzies et al, 200720 Salpeter et al, 200421 Salpeter et al, 200421


WHO Global Tuberculosis Report22 MOH, 20158


0.0057 0.0023


0.03


0.003 0.35 0.64


0.003 0.95 0.80


4


72 72


11,607 12,305 3


0.975 0.667 0.827 3


0.004275–0.007125 0.001725–0.004


0.0225–0.0375 0.00225–0.01 0.07–0.5


0.375–0.85 0.001–0.02 0.80–0.99 0.40–1.00


2–8


36–144 36–144


5,804–23,214 6,153–19,688 3–5


0.85–1.00 0.4–0.8


0.50–0.98 1–5


Salpeter, 200421 Salpeter, 200421


Salpeter, 200421 Salpeter, 200421


del Campo et al, 201223 Pathak et al, 201624


del Campo et al, 201223; Kowada et al, 201516 Assumed based on del Campo et al, 201223 Assumed


NUH NUH NUH NUH NUH


Assumed


Dobler et al, 201525 Dobler et al, 201525 Dobler et al, 201525 Assumed


Note. HCW, healthcare worker; INH, isoniazid; LTBI, latent tuberculosis infection; NUH, National University Hospital; QALY, quality-adjusted life-year; QFT-G, QuantiFERON-TB Gold In-Tube; QOL, quality of life; TB, tuberculosis.


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