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Research news


Exercise may help prevent breast cancer


A hormone released from muscles during exercise may help prevent breast cancer and boost the effects of chemotherapy drugs used to treat it, according to a study carried out at the University of New Mexico (UNM) in the United States. Following on from recent findings that


exercise can slow the growth of breast cancer tumours in mice, new research suggests women who exercise regularly have a 30 to 40 per cent reduced risk of breast cancer and improved survival rates if they do get the disease. The team at UNM built on previous studies which had found that the hormone irisin increases with exercise and stimulates metabolism in select tissues, such as fat. Irisin was administered to both non-cancer and cancerous cells, which selectively killed aggressive cancer cells without negatively affecting normal cells. The researchers observed a 22-fold


increase in cancer cell death compared to untreated cells. When irisin was combined with a commonly used chemotherapy drug, the destruction of cells increased significantly, while cells absorbed less of the drug. This could mean that patients could be given a more tolerable dose of the drug. Details: http://lei.sr?a=M4h5o


Research shows power of walking groups


Walking groups have good adherence and can reduce blood pressure, risk of depression, cholesterol and BMI, according to a review published in the British Journal of Sports Medicine. The Hanson & Jones systematic review and meta-analysis took information from electronic databases, clinical trial registers, grey literature and reference lists, reviewing 42 studies that involved 1,843 people. Reviewers found significant reductions in mean systolic and diastolic blood pressure, resting heart rate, body fat, body mass index, total cholesterol and depression scores. They also found significant mean increases in lung capacity and speed. High levels of adherence were reported


and virtually no side-effects. These findings add fuel to the debate of whether health clubs should be reaching out beyond their four walls and organising community walking groups, to engage those who wouldn’t normally venture into a gym and offer an entry level activity. Details: http://lei.sr?a=V1E5v


18 Short, sharp bursts of HIIT before a high fat meal could protect blood vessel function High fat diet alters behaviour


A high fat diet that changes the mix of bacteria in the gut alters behaviour and creates signs of brain inflammation – even in the absence of obesity – say researchers from Louisiana State


University. Non-obese adult mice received a transplant of gut microbiota from donor mice that had been fed either a high fat or control diet. Recipient mice were evaluated for changes in behaviour and cognition. The animals that received the microbiota


shaped by a high fat diet showed multiple disruptions in behaviour, such as increased anxiety, impaired memory and repetitive behaviour. Other detrimental effects were increased intestinal permeability and markers of brain inflammation. The findings suggest the gut microbiome has


A high fat diet affects the gut microbiota Read Health Club Management online at healthclubmanagement.co.uk/digital


the eventual potential to serve as a target for neuropsychiatric disorder therapies. Details: http://lei.sr?a=S2J2h


May 2015 © Cybertrek 2015 HIIT defence against fatty food


Going for a long run ahead of a night of excess is a familiar ritual for many young people, but working up a sweat with a few sharp sprints may be a better strategy. Scientists at the University of Exeter have


found that a short burst of high-intensity interval training (HIIT) before a high fat meal is the best way for young people to protect blood vessel


function. The new


study found that high-intensity exercise is far more effective than moderate intensity for promoting vascular health in such instances. Cardiovascular diseases are the leading cause of death in the UK, and the underlying process


starts in youth. An impairment in the function of blood vessels is thought to be the earliest event in this process, and this is known to occur in the hours after consuming a high fat meal. The study compared HIIT against moderate- intensity exercise on blood vessel function in adolescent boys and girls after they had consumed a high fat milkshake. It found 25 minutes of moderate-intensity cycling prevented the fall in blood vessel function after the high fat meal. But just eight minutes of high-intensity cycling not only prevented this fall, but improved blood vessel function. Details: http://lei.sr?a=C8t9p


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