FULL-TIME PHARMACIST REQUIRED FOR NORTH COAST PHARMACY
The ideal candidate will have experience working in a busy pharmacy environment. highly organised and has the ability to work under pressurised circumstances. The successful candidate will have a key focus on customer service and building a customer base. An individual keen to develop and grow extra pharmacy services.
Please apply with CV to: Vincent Campbell, Campbell's Pharmacy, 8-9 Dunluce Street, Portrush, BT56 8DN Email:
vincentcampbell@btinternet.com
Closing date: friday 26th May
QUB rESEArChErS In Cf BrEAKThroUgh
researchers at Queen’s University in Belfast have discovered why antibiotics for treating people with cystic fibrosis are becoming less effective and how fat soluble vitamins might offer a viable solution.
A team of researchers led by Professor Miguel Valvano from the Wellcome-Wolfson Institute for Experimental Medicine has discovered why some particularly harmful bacteria are not responding to antibiotics.
The bacteria, Burkholderia cenocepacia, are highly antibiotic resistant and cause severe lung infections in people with cystic fibrosis.
This research study, recently published in the international journal mBio, revealed that the administration of fat-soluble vitamins could increase the effectiveness of the antibiotics used to treat cystic fibrosis infections. lipocalins, the antibiotic-capturing proteins, latch on with more strength to fat-soluble vitamins than to the antibiotics. Therefore, fat-soluble vitamins such as vitamin E could help to improve antibiotic treatment by freeing the antibiotics from the lipocalins and allowing them to
reach the target bacteria to fight the infection.
‘Antibiotic resistance is a global phenomenon which prevents the effective treatment of diseases,’ Professor Valvano explained.
‘our research shows that bacteria can not only resist the action of antibiotics once they are internalised, but can also capture antibiotics before they reach and penetrate into the bacterial cells.
‘This is an exciting and potentially life- changing finding, particularly relevant for cystic fibrosis patients who are chronically infected with multi- resistant bacteria. Armed with this knowledge, we can focus our efforts on finding alternative solutions to more effectively treat the infection in these patients.
‘fat-soluble vitamins can ‘soak up’ the lipocalins before they have a chance to bind the antibiotics, increasing the chances that antibiotics will reach the bacteria. We are now exploring ways to reformulate antibiotics together with relevant vitamins for delivery into cystic fibrosis patients and assess their efficacy, so that patients can benefit from these findings.’
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