vital vitamin K is to this process as well; calcium is less likely to ever each the bone matrix without adequate K.
Vitamin D increases the intestinal uptake of calcium from the gut, but also induces the synthesis of osteocalcin which, as previously mentioned, requires adequate vitamin K to activate!
Why forMS MATTEr: MK4 VS MK7 K2 is available in many homologues known as menaquinones, with menaquinone-4 (MK-4) and menaquinone-7 (MK-7) being the most popular in supplements. MK-4 has evidence supporting its use in bone and circulation health and has traditionally been the most studied. MK-7 has vastly become the most popular isomer however due to demonstrating more favourable characteristics in studies.
As well as having a longer isoprenoid chain, MK-7 also has a longer half life (72 hours half-life approximately,) meaning it is biologically active in the body for longer than both Vitamins K1 and K2 MK-4. not only this, studies have shown that MK-7 demonstrates superior effects on normal blood coagulation compared to MK-4 (3)
and provides a more active
grade of osteocalcin than Vitamin K1(4)
.
Comparative to MK-4, MK-7 has demonstrated superior uptake and subsequently a raised serum levels in subjects. In one particular study comparing two randomized groups
taking 60 µg/day of K2 MK-4 or K2 MK-7, the MK-7 group's level of K2 had risen significantly, whereas the MK-4 group's K2 levels did not rise during the seven-day study(5)
.
noT All K2 MK-7S ArE EQUAl Vitamin K2 MK-7 supplements may be either be processed via
fermentation or via a patented organic process. K2 MK-7 produced via the organic process demonstrates a 100% trans MK-7 isomer profile. In essence, MK-7 produced this way is 100% biologically active, whereas MK-7 produced via fermentation processes can be a mix of both trans and cis forms (cis being inactive).
This organic process produces K2 MK- 7 which is free of common allergens, great news for individuals adverse to soy present in the fermented varieties. As a lipid soluble vitamin, K2 is best absorbed from the gut in the presence of fats, most dependably in an oil capsule format.
K2- ThE nEXT STEP In PrEVEnTATIVE nUTrITIon The importance of vitamin K2 is being noticed, with more individuals opting to take advantage of its bone and circulatory health benefits. Difficult to derive from food, careful consideration should be made when opting for which vitamin K2 to choose to get the best out of the supplement. The research is clear; Vitamin K form matters!
references: 1. okuyama h e. Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. - PubMed - nCBI [Internet].
ncbi.nlm.nih.gov. 2017 [cited 10 April 2017]. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/256556 39 2. geleijnse J, Vermeer C, grobbee D, Schurgers l, Knapen M, Meer I et al. Dietary Intake of Menaquinone Is Associated with a reduced risk of Coronary heart Disease: The rotterdam Study [Internet].
Jn.nutrition.org. 2017 [cited 10 April 2017]. Available from:
http://jn.nutrition.org/content/134/11/3100.long 3. Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient rats - ScienceDirect [Internet].
Sciencedirect.com. 2017 [cited 10 April 2017]. Available from:
http://www.sciencedirect.com/science/article/pii /000629529500202B?via%3Dihub 4. Schurgers l, Teunissen K, hamulyak K, Knapen M, Vik h, Vermeer C. Vitamin K- containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. 2017. 5. Sato T, Schurgers l, Uenishi K. Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. nutrition Journal. 2012;11(1).
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