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72 TABLETING


when handling highly potent APIs and other highly active or cytotoxic powder. Te FilterBox achieves containment to nanogram levels protecting both the product and the operator during operations including charging, sampling, filtration, drying and discharging. Te cleaning procedure can be performed safely and thoroughly as the vessel base and the removable filtration basket can be easily accessed in a contained environment. Interconnecting nozzles and pipes can be dismantled without any containment breach for contained cleaning and maintenance.


Te FilterBox provides a more compact design than traditional separate agitated nutsche filter dryer and containment products, reducing floor space requirement and impact on plant design. Te solution is easily scalable for laboratory to industrial production.


Te system can comprise 0.002m² to 0.05m² filter dryers as part of the GFD range (Fig. 2). Te GFD technology combines filtration, cake washing and drying all in one step and product is fully recovered through the filtration basket. Tis miniature version of a PSL production size filter dryer allows process development during early stages. Due to its


direct scale-up abilities, this vacuum lab filtration and drying unit is ideal for feasibility studies and trials before investing in a large-scale agitated nutsche filter dryer.


Te GFD FilterBox shown


in Fig. 1 includes a Maxi Lab GFD for the API manufacturing of an oncology drug, which is done in Turkey. Te containment performance was tested by a third-party industrial hygienist, Vega Environmental Consultants. Te personal sampling results obtained from the surrogate containment testing to measure airborne levels of surrogate during the use of the PSL GFD FilterBox indicated that the target OEL of less 0.1 µg.m3


, 8h TWA, was likely to be


met (see Table 1). For more information ✔ at www.scientistlive.com/eurolab


Table 1: Personal sampling results expressed as an 8h TWA from Vega


www.scientistlive.com


Camille Flores-Kilfoyle is with Powder Systems Limited (PSL). www.powdersystems.com


Fig. 2. Internal view of the Maxi Lab GFD inside a high containment FilterBox


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