56 SPECTROSCOPY
The COMMERCIAL ADVANTAGES of RAMAN
Linking laboratory and process line with optimised Raman solutions. By Karen Esmonde-White
I
On-line monitoring of a pilot plant process with the Kaiser Pilot probe
ndustrial process development begins in the laboratory and ends in the manufacturing plant. Process development is iterative, complex and can take a long time if not properly controlled. Tere are numerous challenges as the process is scaled up from the laboratory to the pilot plant to manufacturing. A significant challenge is to understand the physical and chemical properties of the process at each scale. Once a process is understood it can become optimised, effectively scaled and properly controlled. Tere are multiple steps involved in understanding a process, including: analysing the process, understanding critical process parameters (CPPs) and what chemical or physical factors affect
A laboratory-scale reactor analysed by a Kaiser MR probe
them, and controlling those process dependent factors. Raman spectroscopy is uniquely suited for this task and has been proven to:
l Facilitate continuous processing/manufacturing approaches
l Provide robust method transferability from laboratory to manufacturing
l Reduce cycle times l Prevent reject product and waste
Scientifically and financially successful Raman applications have been demonstrated at all scales, from at-line in the laboratory to on-line in manufacturing in PAC and PAT environments.1
www.scientistlive.com Examples of Kaiser Optical
Systems’ customers’ processes benefitting from Raman spectroscopy include:
l Pharmaceutical formulations: blending, granulation, coating, drying, tableting, content uniformity
l Pharmaceutical API: reaction chemistry, yield, polymorph form identification, crystallisation
l Polymer: polymerisation blending, extrusion monitoring, crystallinity, density, copolymers
l Biologics/bioprocessing/ biopharmaceutical/biotech: cell culture, fermentation
Two customer examples illustrate the advantages of Raman
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