TABLETING 71


Advances in


Camille Flores- Kilfoyle reports on a laboratory high containment filtration and drying facility


HIGH CONTAINMENT TECHNOLOGIES A


ctive ingredients and pharmaceutical compounds developed in laboratories and R&D centres have increasing potency and require additional protection for the operators and environment. When developing new drugs, the risks at early stages are not always fully understood and a conservative approach should be preferred. Occupational exposure


levels (OELs) set by scientific committees and institutes are increasingly strenuous and


Fig. 1. Laboratory GFD FilterBox: high containment filtration and drying for R&D


containment performance can go as low as 0.1 µg.m3


, eight-hour


time weighted average (TWA). Traditional restricted access barrier system, laminar flow cabinet or fume hood do not provide such a strict controlled environment, but high containment technologies do. Containment technologies such as isolator and glovebox fulfil the above requirement at any scale. ISPE defines containment technology as a “leak-tight enclosure designed to protect operators from


hazardous/potent processes or protect processes from people or detrimental external environments or both.” To provide a safe and ergonomic solution to its laboratory nutsche filter dryer, the GFD, Powder Systems Ltd, a pioneer of high containment technologies, developed the GFD FilterBox (Fig. 1). Te FilterBox consists of a small agitated nutsche filter dryer (GFD) being completely integrated within a PSL isolator, providing high containment


www.scientistlive.com


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88  |  Page 89  |  Page 90  |  Page 91  |  Page 92  |  Page 93  |  Page 94  |  Page 95  |  Page 96  |  Page 97  |  Page 98  |  Page 99  |  Page 100