NEWS |
GREEN TEA EXTRACT AND DIABESITY
In order to ascertain whether green tea truly has this potential, Jae-Hyung Park and his colleagues from the Keimyung University School of Medicine in the Republic of Korea conducted a study, now published in the journal Naunyn- Schmedeberg's Archives of Pharmacology. The active constituents of green tea, which
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have been shown to inhibit intestinal glucose and lipid uptake, are a certain type of flavonoid called gallated catechins. The authors had previously suggested that the amount of gallated catechins necessary to reduce blood glucose concentrations can be achieved from a daily dose of green tea. However, the amount of green tea needed to
vidence has shown that green tea extract may be an effective herbal remedy useful for weight control and helping to regulate glucose in type 2 diabetes.
EXTRACT PLUS COMPOUND FOR CONTROL OF DISEASE They then looked at the effects on the mice of
The effects of green tea extract were comparable to
those found when taking two of the drugs which are currently
recommended for non-insulin dependent diabetes.
eating green tea extract alone, and eating green tea extract plus polyethylene glycol. They compared these against the effects of two other therapeutic drugs routinely prescribed for type 2 diabetes. Results showed that green tea extract in isolation did not give any improvements in body weight and glucose intolerance. However, when green tea extract was given with polyethylene glycol, there was a significant reduction in body weight gain, insulin resistance and glucose intolerance in both normal mice on a high fat diet and diabetic mice. The polyethylene
glycol had the effect of prolonging the amount of time the gallated catechins remained in the intestines, thereby limiting glucose
decrease lipid uptake from the gut is higher and has been shown to have adverse effects in humans. Once in the bloodstream, gallated catechins can actually increase insulin resistance, which is a negative consequence especially in obese and diabetic patients.
Impact on body weight and glucose intolerance For their study, the researchers tested the effects of green tea extract on body weight and glucose intolerance in both diabetic mice and normal mice fed a high-fat diet. To prevent a high dose of gallated catechins from reaching the bloodstream, the authors also used a non-toxic resin, polyethylene glycol, to bind the gallated catechins in the gut to prevent their absorption.
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absorption for a longer period. Interestingly, the effects of the green tea extract in both the intestines and in the circulation were measurable at doses which could be achieved by drinking green tea on a daily basis. In addition, the effects of green tea extract
were comparable to those found when taking two of the drugs which are currently recommended for non-insulin dependent diabetes.
Conclusions The authors conclude that 'dietary green tea extract and polyethylene glycol alleviated body weight gain and insulin resistance in diabetic and high-fat mice, thus ameliorating glucose intolerance. Therefore the green tea extract and polyethylene glycol complex may be a preventative and therapeutic tool
for obesity and obesity-related type 2 diabetes without too much
concern about side effects.' May/June 2013 |
prime-journal.com
IMPACT OF UVA ON PREMATURE SKIN AGEING
A study conducted by researchers at Boston University School of Medicine (BUSM) provides new evidence that long-wave ultraviolet light (UVA) induces a protein that could result in premature skin ageing. The findings demonstrate that aspects of photoageing, the process of skin ageing by chronic exposure to ultraviolet radiation, could be linked to genetic factors that accelerate the ageing process when induced by the environment. The study, published in the Journal of
Investigative Dermatology, was led by BUSM co-authors Thomas M. Ruenger, Professor and Vice Chair of the department of dermatology, and Hirotaka Takeuchi, MS.
Photoageing Photoageing is attributed to continuous exposure to UVA and shortwave ultraviolet light (UVB) rays over a long period of time, and affects skin surfaces most often exposed to sunlight, including the face, ears, hands and neck. The UVA or UVB rays can be from the sun or from synthetic sources, such as tanning beds. Progerin is a protein that has been associated with both normal and abnormal ageing. In Hutchinson Gilford Progeria syndrome, a genetic disorder characterised by a vast acceleration of ageing of most organs, expression and accumulation of progerin is caused by a mutation in the Lamin A gene. In this study, skin cells were cultured and
exposed to UVB or UVA rays and then examined for expression and accumulation of progerin. The results showed that progerin is induced by ultraviolet light, specifically UVA rays, and that this induction is mediated by reactive oxygen species causing alternative splicing of the LaminA gene pre-mRNA. The researchers also note that some aspects
of photoageing should be regarded as a process of damage-accelerated intrinsic ageing and that intrinsic and extrinsic ageing are interdependent.
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