CAT FRIENDLY / Feelin’ the Felines


Topical Parasiticide for Dogs and Cats BRIEF SUMMARY:


See package insert for full prescribing information.


CAUTION: US Federal law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS:


Revolution is recommended for use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications:


Dogs:


Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution also is indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.


Cats:


Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.


WARNINGS:


Not for human use. Keep out of the reach of children. In humans, Revolution may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans in rare instances. Indivduals with known hypersensitivity to Revolution should use the product with caution or consult a health care professional. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water. In case of ingestion by a human, contact a physician immediately. The material safety data sheet (MSDS) provides more detailed occupational safety information. For a copy of the MSDS or to report adverse reactions attributable to exposure to this product, call 1-800-366-5288.


Flammable—Keep away from heat, sparks, open flames or other sources of ignition. Do not use in sick, debilitated or underweight animals. (see SAFETY)


PRECAUTIONS: Prior to administration of Revolution, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Revolution is not effective against adult D. immitis and, while the number of circulating microfilariae may decrease following treatment, Revolution is not effective for microfilariae clearance.


Hypersensitivity reactions have not been observed in dogs with patent heartworm infections administered three times the recommended dose of Revolution. Higher doses were not tested.


ADVERSE REACTIONS: Pre-approval clinical trials: Following treatment with Revolution, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Other signs observed rarely (≤0.5% of 1743 treated cats and dogs) included vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors. Post-approval experience: In addition to the aforementioned clinical signs that were reported in pre-approval clinical trials, there have been reports of pruritus, urticaria, erythema, ataxia, feverand rare reports of death. There have also been rare reports of seizures in dogs. (see WARNINGS)


SAFETY:


Revolution has been tested safe in over 100 different pure and mixed breeds of healthy dogs and over 15 different pure and mixed breeds of healthy cats, including pregnant and lactating females, breeding males and females, puppies six weeks of age and older, kittens eight weeks of age and older, and avermectin- sensitive collies. A kitten, estimated to be 5–6 weeks old (0.3 kg), died 8 1⁄2 hours after receiving a single treatment of Revolution at the recommended dosage. The kitten displayed clinical signs which included muscle spasms, salivation and neurological signs. The kitten was a stray with an unknown history and was malnourished and underweight (see WARNINGS).


DOGS: In safety studies, Revolution was administered at 1, 3, 5, and 10 times the recommended dose to six-week-old puppies, and no adverse reactions were observed. The safety of Revolution administered orally also was tested in case of accidental oral ingestion. Oral administration of Revolution at the recommended topical dose in 5- to 8-month-old beagles did not cause any adverse reactions. In a pre-clinical study selamectin was dosed orally to ivermectin-sensitive collies. Oral administration of 2.5, 10, and 15 mg/kg in this dose escalating study did not cause any adverse reactions; however, eight hours after receiving 5 mg/kg orally, one avermectin-sensitive collie became ataxic for several hours, but did not show any other adverse reactions after receiving subsequent doses of 10 and 15 mg/kg orally. In a topical safety study conducted with avermectin-sensitive collies at 1, 3 and 5 times the recommended dose of Revolution, salivation was observed in all treatment groups, including the vehicle control. Revolution also was administered at 3 times the recommended dose to heartworm infected dogs, and no adverse effects were observed.


CATS: In safety studies, Revolution was applied at 1, 3, 5, and 10 times the rec- ommended dose to six-week-old kittens. No adverse reactions were observed. The safety of Revolution administered orally also was tested in case of accidental oral ingestion. Oral administration of the recommended topical dose of Revolution to cats caused salivation and intermittent vomiting. Revolution also was applied at 4 times the recommended dose to patent heartworm infected cats, and no adverse reactions were observed.


In well-controlled clinical studies, Revolution was used safely in animals receiving other frequently used veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos and dips.


STORAGE CONDITIONS: Store below 30°C (86°F).


HOW SUPPLIED: Available in eight separate dose strengths for dogs and cats of different weights. Revolution for puppies and kittens is available in cartons containing 3 single dose tubes. Revolution for cats and dogs is available in cartons containing 3 or 6 single dose tubes.


NADA 141-152, Approved by FDA.


REVOLUTION is a registered trademark of Pfizer Inc. ©2012 Pfizer Inc. All rights reserved.


cat-friendly is also an ongoing process; we all need to keep reminding each other not to rush our treatments and stay in the cat ‘Zen moment.’”


Visits and revenues increase Frontier Veterinary Hospital, PC, of


Hillsboro, Ore., has seen many positives since it began instituting cat-friendly practices on its own in 2009 that culmi- nated with CFP certification in 2012. One upshot has been the increase in


its feline business, said Sara Fleissner, practice development director. “The percentage of our total business


that is feline did increase from 28% in 2010 to 32% in 2012, but the increase in revenue during that time was 22% while visits were up 20%. It means that we had 736 more feline visits in the first 9 months of 2012 compared to the same period in 2010.” “By creating a sort of ‘cat practice


within a practice,’ we have both filled a need for cat owners and created oppor- tunities for our practice,” said Fleissner. The steadily increasing number of active cat patients and cat visits is “impres- sive, especially considering the economic environment of the last few years.” The staff’s improved handling prac-


tices, level of care and confidence have produced a pleasant side effect: increased interaction among the Patient Care team and clients, which created more opportu- nities for education and bonding. In addi- tion, she said, the Client Care team doesn’t “mind bragging to the clients about our CFP status and the things we have done to improve their cat’s experience at Frontier.” Fleissner highlighted some points: • While they implemented AAFP Handling Guidelines before applying for the CFP program, other prac- tices may need encouragement to implement them. “Educating both technicians and customer service personnel to identify cat body lan- guage and altering the approach to fearful or aggressive cats takes some finesse and time to retrain routines.”


Distributed by: Pfizer Animal Health Division of Pfizer Inc. New York, NY 10017


www.revolutionpet.com


10309503 April 2012


Trends magazine, May 2013


• Practicing the use of towels for restraint on their own cats helped the technicians feel comfortable and confident with this type of holding. “A very small investment in non-traditional tools—nice thick towels, bath mats for use on exam tables, and toys to use for distrac- tion in the exam room—more than paid for itself.”


• Providing a cat-only exam room— something Frontier already had in place—is worth doing. Client response has been “overwhelming,” she said.


• Instead of a broad rollout, Frontier started out case-by-case to address issues as they arose. For example, it had to develop a customer service policy and communication tech- niques for visibly uncomfortable or squeamish clients as well as those who attempt to handle their cats while treatments are performed.


One challenge: veterinary profession- als who do not enjoy treating cats. “In my experience, this is primarily


due to fear or a lack of training. Fortu- nately, these are both things that proper coaching can improve if managers and team leaders take the time to imple- ment a thoughtful and staff-empowering approach,” said Fleissner. The biggest potential obstacle: getting


your staff on board with the CFP pro- gram. “It is essential to have your entire staff and doctor team ‘buy in,’ though creating ‘buy in’ for any new initiative is a significant challenge for many veteri- nary managers,” said Fleissner. “At the practice level, projects like


the CFP and AAHA accreditation pro- cesses, when properly and thoughtfully implemented by management, really do help bring your team together. Everyone working toward a common goal that ben- efits both our patients and our business is truly a win-win!” n


Maureen Blaney Flietner is a freelance writer, photographer and design specialist based in Wisconsin.


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