EPIDEMIOLOGY


In the past, international studies of IBD used a mixture of methods, different definitions of IBD and different definitions of the study population, etc. The quality of research was not always high and the underlying variation resulted in a broad range of results. This made it difficult to do precise international comparisons. The Canadian IBD Epidemiology Database Study set a new standard in the measurement and reporting of IBD epidemiology. It is encouraging to see that recent studies have adopted this rigorous methodology.


Canadian researchers have recently conducted a landmark comprehensive review of the literature, to determine changes in worldwide incidence and prevalence of IBD in different regions and over time.37


They identified 260 research papers that contributed data to this


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question. Figures 11 and 12 show the results across the globe, focusing on data reported after 1980. Research in developing countries is comparatively scarce, but the work that has been done has been reported since 1980. Research methodology in the developing world remains inconsistent in quality, and generally underestimates results.


Figure 11: International Comparison, Crohn’s Disease (CD) 


Molodecky 2012 


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THE IMPACT OF INFLAMMATORY BOWEL DISEASE IN CANADA 39


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