| RESEARCH ROUND-UP
12 weeks compared to baseline. The MASI scores were also significantly reduced on both tested sides. However, lightening of pigmentation induced by TA gel was neither superior nor different (p > 0.05) compared to its vehicle although erythema was significant on the TA-applied site (p < 0.05). Conclusions: Although lightening of pigmentation was obtained, the results were not significant between the two regimens. However, topical TA produced erythema.
SYMPTOMS OF TESTOSTERONE DEFICIENCY IN EARLY MIDDLE AGED MEN
Spetz Holm ACE, Fredrikson MG, Hammar ML. Aging Male 2012; 15(2): 78–84
S YMPTOMS OF TESTOSTERONE deficiency and concentrations of
testosterone (T) and bioavailable testosterone (BT) were studied in 35- and 45-year-old men. Methods: A questionnaire, was sent to all 35- and 45-year-old men in Link˜ ping, Sweden (n = 1998). The questionnaire has earlier been used for 55- to 75-year-old men and included demographic data, medical history, different symptoms possibly of T deficiency and the 10 questions from the ÒADAM-questionnaireÓ . Totally 200 men randomly selected among the men who answered the questionnaire were asked to give blood samples for analysis of T- and BT-concentrations. Results: A total of 38.7% of the questionnaires were returned and analysed, and 43.5% of the 200 randomly selected men gave blood samples. The older age group reported more symptoms that may be connected to low B and BT and had lower T- and BT-concentrations. Less
strong erections and higher alcohol consumption
preservative-free tafluprost in newly diagnosed patients and to confirm its efficacy in lowering intraocular pressure (IOP). Methods: Na“ve patients were submitted to an ophthalmic examination, including ocular surface status and quality of life evaluation. All examinations were performed at baseline and after 1 and 6 months. Results: 28 patients were enrolled and treated with tafluprost, once a day, in the evening. TF-BUT changed from 9 (interquartile range (IQR) 6 Ð 11) s at baseline to 10 (IQR 7 Ð 10) s at 1 month (p = 0.106) and 9 (IQR 6 Ð 12) s at 6 months (p = 0.003). No eye developed corneal staining. Quality of life was (median (IQR)) 91.6 (79.2 Ð 95.8) at baseline and 95.8 (66.7 Ð 100) at 6 months (p = 0.62). Only a few adverse events occurred during the follow-up period (three
O
BJECTIVES: THE AIM OF THIS STUDY was to
evaluate the safety of
were associated with lower concentrations of BT in 45-year-old men. Conclusions: The burden of symptoms possibly related to low T concentrations were higher in 45-year-old men, and BT and T were lower. However, due to the low answer frequency and number of blood samples analyzed no general conclusions can be drawn.
EFFICACY AND OCULAR SURFACE TOLERABILITY OF PRESERVATIVE-FREE TAFLUPROST 0.0015%: A 6-MONTH, SINGLE-BLIND, OBSERVATIONAL STUDY ON NAÏVE OCULAR HYPERTENSION OR GLAUCOMA PATIENTS
Rossi GCM, Pasinetti GM, Raimondi M et al. Expert Opin Drug Saf 2012; 11(4): 519–25
patients experienced ocular burning and one developed redness). The mean IOP reduction was 5.5 mm Hg (95% CI 3.8 Ð 7.2). The median (IQR) baseline IOP was 18.7 (15 Ð 23.7) mm Hg; 14 (13 Ð 16) mm Hg and 16 (14 Ð 16) mm Hg (p < 0.0001) after 1 and 6 months, respectively. Conclusion: No patient developed ocular surface disease and quality of life perception was preserved. Preservative-free tafluprost is therefore an effective drug that is safe for the ocular surface after 6 months of daily therapy.
AESTHETIC RECONSTRUCTION OF A DEFECT IN THE SKIN OF THE UPPER LIP USING A HATCHET FLAP
Kuwahara M, Yurugi S, Mashiba K et al. J Plast Surg Hand Surg 2012; 46(2): 80–4
R
ECONSTRUCTION OF THE UPPER LIP requires symmetrical reconstruction of the
free border according to the aesthetic principle. We have reconstructed this area with a hatchet flap, so that the scars match the subunit line as far as possible by rotation and advancement of the flap. We operated on six patients. The lower pedicled flap was used in 4 cases and the upper pedicled flap in 2, who also needed reconstruction of the vermillion. In one patient the scar did not match the nasolabial fold. For the upper pedicled cases, scars made on the vermillion were not conspicuous. However, trap door deformity occurred in half, which was a disadvantage. We think that our flap is useful, because it leaves a minimal scar in an inconspicuous area.
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