| NUTRACEUTICALS | ARTICLE Within the RISTOMED study, orange
peel extract supplementation contributed to anti-inflammation and mood improvement, as documented by two different pre-clinical studies in rodents.
PATRIZIA D’ALESSIO, University Paris Sud-11 and Biopark Cancer Campus 1, France; RITA OSTAN, Department of Experimental Pathology, University of Bologna, Italy; LUZIA VALENTINI, Charité—Universitätsmedizin Berlin, Section of Nutritional Medicine of the Deptartment of Gastroenterology, Berlin, Germany; ISABELLE BOURDEL-MARCHASSON, CHU de Bordeaux, University of Bordeaux, France; ALESSANDRO PINTO, Sapienza University of Rome, Experimental Medicine Department—Medical Physiopathology, Food Science and Endocrinology Section—Food Science and Human Nutrition Research Unit, Italy; FABIO BUCCOLINI Voxnet, Rome Italy; CLAUDIO FRANCESCHI, Department of Experimental
Pathology, University of Bologna, Italy;
MARIE C BENE. CHU Nancy and University of
Lorraine, France. email:
patriz.dalessio@gmail.com
ABSTRACT Full title Gender differences in response to dietary supplementation by orange peel extract in elderly people in the RISTOMED study: impact on quality of life and inflammation.
A number of health issues have shown to be questionable when considered from the perspective of gender differences. Quality of life parameters in particular, seem to be experienced differently by men
T
and women. Depression — one of the hallmarks of the ageing population, particularly affecting women because of greater longevity — has a causal role in the development and course of cardiovascular diseases. Epidemiological data demonstrate that depression and anxiety are approximately twice as common in women as in men. This gender difference emerges during adolescence and persists later in life, and into old age. Furthermore, it is well recognised that inflammation contributes to the development of depression. In this article, the authors report a study performed in elderly
WENTY-FIVE YEARS OF GENDER issue analysis have contributed to the reclassification of diseases. Among cardiovascular diseases, myocardial infarction is indeed the number one cause of death in women, but as its
symptoms are different to those seen in men, it has not been recognised as such for a long time. Although age-specific stroke incidence is higher in men1
, women
are generally more affected by strokes at an older age owing to their increased longevity. Consequently,
healthy men and women, examining biological and behavioural responses after 56 days of a specifically developed dietary programme, with or without anti-inflammatory dietary supplementation, with an orange peel extract (OPE) containing d-Limonene; the European study RISTOMED. The authors show an impact of both gender and initial inflammation status on the effects of dietary control. OPE was more efficient in subjects with an initially high inflammatory status and improved both interleukin 6 (IL-6) levels and depression scores in women.
strokes in women have been reported to be of a greater severity and to result in a worsened outcome2
. Even if
there are still conflicting data, these findings may be partly explained by the fact that women are often older and have a greater number of comorbidities at the time of stroke onset and diagnosis2
. The effectiveness of
primary prevention of stroke and other cardiovascular events with aspirin has been tested in a number of trials, but three of these did not include women3
. Data
seem to suggest that aspirin is able to prevent myocardial infarction in men and stroke in women.
KEYWORDS gender, quality of life, nutraceutical, depression, disease, orange peel extract
prime-journal.com | July/August 2012 ❚ 31
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