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CORD BLOOD IN THE CLINICS TODAY AND FUTURE DIRECTIONS


By Dr. Cherie Daly, Director, CSD Consulting, Antwerp, Belgium


HEMATOPOIETIC STEM CELL TRANSPLANTS Initial work by Knudtzon in the 1970’s and Broxmeyer and colleagues in the early 1980’s discovered that umbilical cord blood (UCB) contained hematopoietic stem cells (HSCs) similar to those in bone


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marrow and that these cells could be collected, processed and cryopreserved. The first attempt to transplant UCB stem cells as an alternative to bone marrow stem cells was in 1972, with the first successful recorded and published umbilical cord stem cell transplant


performed in France in 1988 for a boy with Fanconi’s Anemia. The donor was his sister and her umbilical cord blood was collected at birth and used in the transplantation. Today, the patient is healthy and cured of the condition. This success, followed by further


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