STORY’ ORASURE´S
‘HISTOFREEZER®
Article provided by OraSure
reatment modalities for benign skin disorders include a wide variety of options such as destructive-therapy, chemotherapeutic modality, immunological modulation and antivirals among others. No single treatment is uniformly effective, results are rarely immediate, and multiple treatment cycles may be necessary depending on the lesion type, depth and thickness of skin. Common destructive modalities include Cryotherapy/Cryosurgery. Historical cryosurgical methods for treatment of benign skin lesions included using dry ice, nitrous oxide or liquid nitrogen. All these technologies freeze the skin tissue at temperature below -60°C. Histofreezer® is an alternative portable cryosurgical system that uses an environmentally safe mixture of dimethyl ether and propane (DMEP). The dispensing of the gas mixture through a specific applicator saturates the foam-applicator and reaches a temperature of approximately -55°C via heat vaporization. Dr. Willem Swart, a Dutch physician, invented this cryosurgical system as an alternative to liquid nitrogen for treatment of benign lesion and warts. The DMEP-system freezing temperature is less aggressive than liquid nitrogen (-196°C), but more than adequate for treating benign lesions and warts. It is easily tolerated by patients, and offers a low risk of scarring, blistering or depigmentation. A saturated 5mm Applicator maintains a temperature of approximately -55°C for up to 2 minutes. Therefore, treatment of two lesions or lesion sections is possible. For example, a 1,0cm diameter lesion sectioned into two parts of approximately 0,5 cm can be treated with the 5mm-diameter Applicator. Published, randomized, multi-centre controlled clinical trials comparing efficacy, tolerance and safety of this product with liquid nitrogen demonstrate no clinically relevant differences when treating benign skin lesions. ■
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Arab Health Issue 4 2011 25
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