chelated Cu was better absorbed than the inorganic source of the trace mineral.
Figure 3: Effect of MINTREX Cu supplementation on tissue Cu deposition
mg/kg + 60 %
perspective and provides new opportunities for efficient nutritional solutions. In commercial feed, a great amount of phosphorous is bound in the form of phytic acid/phytate, which is poorly available for the animal. Phytase is added in the diet to cut out phosphorous from plant origin making it more available for digestion. It has been shown that the efficiency of phytase is improved by replacing copper sulphate with Methionine-Hydroxy-Analog chelated copper. This is linked to the fact that phytate from the diet has a strong binding potential for positive charged molecules such as copper, zinc and others. When using copper sulfate in the diet, the trace mineral source will dissociate in the digestive tract releasing copper. This free copper can interact with phytic acid to form insoluble phytate-copper-complexes. In such a complex added phytase cannot liberate phosphorous from the phytate, which is illustrated in a simplified graph in Figure 4.
Practical application by replacing copper sulfate with Mintrex Cu How this improved copper bioavailability translates into better health and performance under commercial conditions was tested together with a leading European swine producer. The chelated copper source was used on a farm with 700 weaned piglets per group by comparing identical copper levels in two diets. In the control diet copper sulphate was added at 150 ppm Cu. In the second diet copper sulfate was replaced by HMTBa-chelated copper at identical levels (150 ppm). After 57 days, animals in the Mintrex group were 1.7 kg heavier
and the feed conversion reduced by 0.11 points (p<0.05). Per each 1 kg of weight gained piglets in the control group used 1.64 kg of feed compared to only 1.53 kg for piglets in the Mintrex group. Taking into consideration a total of 25 kg weight gain in the Mintrex group, this lower feed consumption of 110 g per piglet is equivalent to 2.75 kg of feed. A unit with 300 sows and 30 weaned piglets per sow and year would need about 25 tonnes less feed due to the application of copper chelated with HMTBa. Together with the reduced mortality and less medication costs, the replacement of CuSO4 with the highly available copper source significantly improves the economic benefit for the farmer.
Tabel 1: Replacing CuSO4 by Mintrex Cu in a commercial trial with piglets
Initial Weigh (kg) Final Weight (kg) Days (d)
Daily Gain (g/d) Mortality (%) Runts (%)
Feed Conversion (kg feed/kg gain)
CuSO4 6.64
30.8 57
424 5.7
12.1 1.64
Mintrex Cu 6.99 32.4 57
446 0.0 6.4
1.53
p-value 0.28 0.08 .
0.02 0.02 0.03
0.004
Interaction of Mintrex Cu with Phytase Recent data and new insights into the interaction of chelated trace minerals with phytase puts the usage of HMTBa-Chelates into a new
PAGE 34 MARCH/APRIL 2018 FEED COMPOUNDER
Figure 4: Simplified model: Phytate binding to copper (Phytate- Copper-Complex) making copper and phosphorous unavailable for the animal
Copper and phosphorous in the phytate-mineral complex is poorly
available for the animal and therefore excreted into the environment. In addition, the added phytase cannot work on this complexed copper- phytate-molecule to release the needed phosphorous. As a result, both essential minerals (copper and phosphorous) cannot be used by the animal and are excreted. Mintrex Cu on the other hand, avoids such antagonism as the
copper is “protected” by two molecules of HMTBa. Copper will not bind to phytate allowing the phytase to release the phosphorous. In addition, the copper is highly available and ensures optimal supply to the animal. A recent trial in piglets has demonstrated this phytase-copper
interaction in an impressive way (Figure 5). Weaned piglets (d 28) received identical levels of added copper (80 ppm) either as copper sulphate or Mintrex Cu. Both groups were further divided by using a diet with or without phytase (500FTU/kg): Mintrex Cu
• •
Mintrex Cu + Phytase
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