Lube-Tech PUBLISHED BY LUBE: THE EUROPEAN LUBRICANTS INDUSTRY MAGAZINE
products in the amount of LDH release they induced were observed at both concentrations. At both concentrations product B induced the highest cell damage with product C producing the lowest.
summarized in Table 4 and Figures 3 and 4. Again, as expected the 10% product dilution induced a higher LDH-release as a measure of cell damage compared to the 5% product dilution for all products tested. Clear differentiation between product A, B and C on cornea models was only seen after application of the products at 10% dilution. At 5% product dilution no significant difference was detected in the LDH released by the three products.
Figure 1: Course of LDH-release from epidermis models after treatment with products A, B and C in 5% product dilution. Values are shown as % of negative control (n=4).
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Figure 3: Course of LDH-release from cornea models after treatment with products A, B and C in 5% product dilution. Values are shown as % of negative control (n=4).
Figure 2: Course of LDH-release from epidermis models after treatment with products A, B and C in 10% product dilution. Values are shown as % of negative control (n=4).
Figure 4: Course of LDH-release from cornea models after treatment with products A, B and C in 10% product dilution. Values are shown as % of negative control (n=4).
A similar picture was seen after application of the products to cornea models. Since cornea models are more sensitive to chemical noxes, a shorter application time was chosen before measuring LDH in this test system. The data generated with cornea models is
In practice skin problems with working fluids often appear to be due to contamination or chemical changes in the product during
LUBE MAGAZINE 79 JUNE 2007 3
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