haematology analysis. The treatments were well tolerat- ed with only a mild transient swelling observed in two piglets in the Forceris® group. The piglets treated with Forceris® had higher Hb, Hct, MCV and Hb concentrations, as well as significantly higher plasma iron and transferrin saturations and a low- er TIBC than those treated with iron dextran based prod- uct. Moreover, after treatment, no animals in the Force- ris® group but 17% of piglets in the iron dextran based product group had Hb levels < 9 g/dL indicative of anae- mia. These results suggest that both products were safe (Figure 7) and effective for the prophy laxis of IDA in pig- lets, although the prevention of IDA was superior for Forceris® compared to iron dextran based.
○ References • Bhattarai S, Nielsen JP. Early indicators of iron deficien- cy in large piglets at weaning. J Swine Health Prod 2015; 23(1):10-17.
• Hinney B, Cvjetkovic V, Espigares D, et al. Cystoisospora suis Control in Europe Is Not Always Effective. Front. Vet. Sci 7:113. doi: 10.3389/fvets.2020.00113.
• Hiob L, Holzhausen I, Sperling D, et al. Efficacy of an in- jectable toltrazuril-gleptoferron (Forceris®) to control coccidiosis (Cystoisospora suis) in comparison with iron supplemented piglets without anticoccidial treat- ment. Vet Parasitol X. 2019;1:100002.
• Joachim A, Ruttkowski B, Sperling D. Detection of Cystoisospora suis in faeces of suckling piglets – when and how? A comparison of methods. Porcine Health Manag 2018b;4:20.
• Joachim A, Schwarz L. Coccidia of swine: Eimeria spe- cies, Cystoisospora (syn. Isospora) suis. In: Mehlhorn, H. eds. Encyclopedia of Parasitology. Heidelberg: Springer, 2015. doi: 10.1007/978-3-642-27769-6_3487-1.
• Joachim A, Shrestha A, Freudenschuss B, et al. Comparison of an injectable toltrazuril-gleptoferron (Forceris®) and an oral toltrazuril (Competitor 1®) + in- jectable iron dextran for the control of experimentally induced piglet cystoisosporosis. Parasit Vectors 2018a; 11(1):206- 2797.
• Maes D, Steyaert M, Vanderhaeghe C, et al. Compari- son of oral versus parenteral iron supplementation on the health and productivity of piglets. Vet Rec. 2011;168:188. doi: 10.1136/vr.c7033.
• Maes D, Vyt P, Rabaeys P, et al. Effects of toltrazuril on the growth of piglets in herds without clinical isos- porosis. Vet J. 2007;173(1):197-9. doi: 10.1016/j. tvjl.2005.07.002.
• Mundt HC. Isospora suis infection in piglets. J Anim Protozooses 2005;20(1):1-12.
• Perri AM, Friendship RM, Harding JSC. An investigation of iron deficiency and anemia in piglets and the effect
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of iron status at weaning on post-weaning perfor- mance. J Swine Health Prod 2016; 24(1):10-20.
• Šperling D, Karembe H, Vaňhara J, et al. Anémie selat z nedostatku železa – stále aktuální téma. Veterinářství 2020;70(4)263-266.
• Sperling D, Freudenschuss B, Shrestha A, et al. Com- parative efficacy of two parenteral ironcontaining preparations, iron gleptoferron and iron dextran, for the prevention of anaemia in suckling piglets. Vet Rec Open 2018;5:e000317. doi:10.1136/vetreco- 2018- 000317.
• Svoboda M, Drabek J. Iron deficiency in suckling pig- lets: etiology, clinical aspects and diagnosis (A review). Folia Vet 2005; 49:104-111.
Figure 8 - Individual and mean ±sds of haemoglobin levels (g/dl) following an intramuscular application of 200mg iron doses to piglets as Forceris or iron dextran based product. Categories of red: anaemic (Hb <9g/dl), green 9≤Hb≤ 11 g/dl, blue Hb > 11 g/dl according to Bhattarai and Nielsen and Perri et al.
Forceris®
10 12 14
8
0 2 4 6
2 18 Day of life 31
10 12 14
0 2 4 6 8
2 18 Day of life 31 Iron Dextran Based product
Fluorescence of individual oocysts in microscopic fields during an auto fluor- escence examination.
Hemoglobin (g/dL)
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