7
To date column 1 combined with method A is predominantly used for new project analysis (>90%). Column 2 has been used for highly polar analytes that overloaded on column 1 and for improved resolution of complex volatile samples. These two columns have been set up as open access on 30% of our GC instruments (the value stream map of this process is illustrated in Figure 6) and column 1 has been set up as open access on a GC-MS. The resulting standard set up of instruments and reduced results turn around time has lead to improvements of GC support to projects through:
• Completed analysis; results are generated in sufficient time to support project decisions
• Increased instrument capacity and availability; multiple projects are using the same instruments
• Increased availability of a local instrument; an open access system is available in every area of the analytical and synthetic chemistry departments
• Increased colleague engagement; over 50% of synthetic chemists have been trained to use GC
• Increased analytical support to projects; data has shown the standard set up instruments are performing over 4 times the analysis compared with traditionally set up instruments
• Increased process understanding; feedback shows in-process analysis is routinely performed
• Enhanced learning: Experts can focus their time on problematic analysis
• Enhanced learning: The methods provide direct alignment between GC-FID and GC- MS instruments
Additional benefit will be a reduction in batch failure due to method error. Increased data volume produced by multiple users on multiple instruments, means method variance can be monitored and addressed.
Control To support continuous improvement GC usage and instrument availability is now routinely monitored and feedback is provided by the user to ensure the defined and standardised suite of methods are being used. An initial roll out of training was delivered to our department and GC training is incorporated to the induction package for all new starters.
Figure 5: Project examples using Column 1 modified oven parameters to improve peak shape for a thermally sensitive compound. Chromatograms 1 Method A, chromatogram 2; initial oven temperature of 180°C, temperature ramp 5°C/min until 240°C. Positional isomer is seen at RT=11.0 minutes.
Figure 4: Project examples using Column 1 Method A. Chromatograms 1 and 3: High efficiency is demonstrated by resolution of positional isomers. Chromatograms 2 and 3: High inertness is demonstrated by good peak shape for reactive analytes (analytes with protection group chemistry)
Figure 6: Value Stream Map of standardised GC Process. Areas highlighted in orange are identified as business value activities; areas highlighted in green are identified as value adding activities. a when second person is performing analysis. bBased on 6 samples with 10 minute total run time. c
Required only Indicates
wait times (delays). The seven categories of waste are highlighted by the letters T I M W O O’ D, definitions are detailed in Table 2.
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