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February / March 2012 Foreword
Welcome to the seventeenth edition of Chromatography Today and the first of the New Year. This edition spotlights Gas Chromatography, with many of the papers contained in this edition being provided by the presenters from the recent successful Chromatographic Society meeting held on ‘Advances in GC’.
This topic area has seen a resurgence of interest in the past few years as the technology has brought new and important developments in sample introduction, separation and detection.
The first paper from Karen Rome at Astra Zeneca looks at the implementation of GC technologies in her company and describes their attempts to improve the efficiency of current GC method development and support processes.
A combination of new ‘lean sigma methodologies’ and the use of advances in column technologies are described.
The next article comes from Sam Whitmarsh a recent recruit to Tom Lynch’s highly regarded Investigational Analysis Team at BP. Sam describes his work on Ionic Liquid Stationary Phases and their application in the analysis of polar components of fuels and lubricants. The paper explores both one and two dimensional separations and highlights the need of column sets being matched to sample composition.
In the paper from Dirk Krumwieder and Heinx Mehlmann both from the POPs Centre of Excellence of Thermo Fisher Scientific (Bremen) they describe the concept of Time controlled Cryogenic Zone Compression (timed CZC).
Results documented show that this novel GC tool used along with MS can yield at least a tenfold increase in signal intensity.
Dan Carrier from Anatune then looks at other possible sample enrichment techniques in his paper entitled ‘Trace level analysis of aqueous samples by Dynamic Headspace (DHS).’
This article compares DHS with other sample enrichment techniques such as Solid Phase Microextraction (SPME), and Stir Bar Sorptive Extraction (SBSE) using Twister stir bars, and compares results from a herbal based liquor and three different orange juices.
In another paper from Thermo Scientific, Peter Morgan, Tony Edge (A new recruit to the Chrom Soc Committee) and Ruth Lewis, look at the use of guard columns for both GC and HPLC. In the first part of the article they investigate the effect of removing the front part of a column when there is an integrated guard present and when there is not one present.
The second looks at the use of an integrated guard column using a press fitting to determine if there is any difference in performance.
Alan Handley - President of the Chromatographic Society
Dianne Turner who runs the successful Anthias GC Training courses provides the next article. The paper describes the worked carried by Dianne and a number of colleagues at the Open University on ‘A Matter of Taste.... Flavour profiling by GCxGC-qMS/FID’. She looks at the separation of complex samples by GCxGC with the emphasis on lower cost GCxGC approaches.
The final paper/application note is provided by Ken Lyman from Agilent Technologies, Wilmington. In his paper entitled “Inert GC flow paths have never been more critical” he states that every stage of the flow path can degrade your results, from the inlet liner to the ion source. He highlights some of the issues along with a case study and provides a list of best practices.
As in keeping, the second part of the “Foreword” allows me to report on The Chromatographic Society.
I am pleased to announce the 2012 Chromatography Society Medals Winners are Professor Ed Yeung (Martin Medal) and Dr Monika Dittmann (Jubilee Medal). Dr Paul Ferguson the Chromatographic Societies Vice President references the two winners in his article in this edition.
The next planned meeting for the Chromatographic Society is on 14-15th March, ‘Chromatographic Characterisation and Purification Techniques for BioPharm. Focusing on Monoclonal Antibody derived drugs’. Followed by 30th/31st May “Separation Science in an Evolving Pharmaceutical Industry”
More details of the meetings are available on The Societies website.
http://www.chromsoc.com/
ChromsocEvents.aspx
All the best for 2012 Alan.
Next Issue - Coated Shell Technologies To be included call us on +44(0)1727 855574 or
info@chromatographytoday.com
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