40 May / June 2017 Conclusions
Complex multi residue pesticide analysis was demonstrated using both LC and GC analysis on the same tandem quadrupole instrument. Analysis methods were generated and maintained using Quanpedia databases, making method generation and maintenance fast and simple. Although the multi residue methods contained approximately 200 compounds each, the reliable scanning speed of the tandem quadrupole mass spectrometer employed (Xevo TQ-S micro) produced accurate and precise measurements. The performance for the determination of pesticide residues analysed in four matrices of varying complexity complied with the SANTE guidelines for pesticide residue analysis. Detection at the EU default maximum residue limit of 0.01 mg/kg was easily achieved for >99% of the pesticides analysed with good precision (RSDs <10%) for most analytes in the food samples. Having the flexibility of the MS Universal Source architecture to provide access to both LC-MS/MS and GC-MS/MS on the same instrument, allows for an increase of laboratory efficiency, while maintaining required sensitivity and repeatability.
References
1. D Shah, E McCall, G Cleland. Single LC-MS/MS Method for Confirmation and Quantification of Over 400 Pesticides in a Complex Matrix Without Compromising Data Quality. Waters Application Note no. 720005559EN. January, 2016.
2. T Kovalczuk, M Jech, J Poustka, J Hajslova. UPLC-MS/MS: A novel challenge in multiresidue pesticide analysis in food, Analytica Chimica Acta, 577, 2006.
3. M Tienstra, T Portoles, F Hernandez, J G J Mol. Fast gas chromatographic residue analysis in animal feed using split injection and atmospheric pressure chemical ionisation tandem mass spectrometry. J. Chrom. A. 1422, October, 2015.
4. L Cherta, T Portoles, J Beltran, E Pitarch, J G Mol, F Hernandez. Application of gas chromatography-mass spectrometry with atmospheric pressure chemical ionisation for the determination of multiclass pesticides in fruits and vegetables. J. Chrom. A. 1314: 224- 240, November, 2013.
5. European Commission. SANTE/11945/2015. Guidance document on analytical quality control and method validation procedures for pesticides residues analysis in food and feed. 2015, rev. 0.
6. AOAC Official Method 2007.01. Pesticide residues in foods by acetonitrile extraction and partitioning with magnesium sulfate. 2013.
Pesticides in GC Method 2-Phenylphenol
4,4'-Methoxychlor olefin Acetochlor Acrinathrin Alachlor
Allidochlor
Anthraquinone Atrazine
Azinphos-ethyl Azinphos-methyl Benfluralin Bifenthrin Bioallethrin Biphenyl
Bromfenvinphos
Bromfenvinphos-methyl Bromophos-ethyl Bromophos-methyl Bromopropylate Bupirimate Captafol Captan
Carbophenothion Carfentrazone ethyl Chlorfenapyr
Chlorfenvinphos Chlorobenzilate Chloroneb
Chlorothalonil Chlorpropham Chlorpyrifos
Chlorpyrifos-methyl Chlorthal-dimethyl Chlorthiophos 1 Chlorthiophos 2 Chlorthiophos 3 Chlozolinate Clomazone Coumaphos Cycloate
Cyfluthrin 1 Cyfluthrin 2 Cyfluthrin 3 Cyfluthrin 4
Cyhalothrin, lambda- Cypermethrin 1 Cypermethrin 2 Cypermethrin 3 Cypermethrin 4 Cyprodinil DDD, o,p'- DDD, p,p'- DDE, o,p'- DDE, p,p'- DDT, o,p'- DDT, p,p'-
Deltamethrin Diallate Diazinon
Dichlofluanid Dichloroaniline, 3,4'- Dichlorobenzophenone, 4,4'-
Diclobenil Dicloran
Dimethachlor Diphenamid
Diphenylamine Edifenphos
Endosulfan ether Endosulfan II
Endosulfan sulphate Endrin aldehyde EPN
Ethalfluralin Ethion Ethylan
Etofenprox Etridazole
Fenamiphos Fenarimol
Fenchlorphos Fenitrothion Fenpropathrin Fenson
Fenthion
Fenvalerate 1 Fenvalerate 2 Fipronil
Fluazifop-P-butyl Fluchloralin
Flucythrinate 1 Flucythrinate 2 Fludioxonil
Fluquinconazole Flusilazole Flutolanil Flutriafol Folpet
Fonofos
Hexachlorobenzene Hexazinone Iodofenfos Iprodione Isazophos Isodrin
Isopropalin Lenacil
Leptophos Linuron
Malathion Metalaxyl
Metazachlor Methacrifos Methoxychlor
Methyl parathion Metolachlor Mevinphos MGK 264 1 MGK 264 2 Myclobutanil
N-(2;4-Dimethylphenyl)formamide Nitralin Nitrofen
Oxadiazon
Oxyfluorfen Paclobutrazol
Parathion Pebulate
Penconazole Pendimethalin
Pentachloroaniline
Pentachlorobenzonitrile Pentachlorothioanisole Permethrin, cis- Permethrin, trans- Phenothrin 1 Phenothrin 2 Phorate
Phosalone Phosmet
Piperonyl butoxide Pirimiphos-ethyl Pirimiphos-methyl Prochloraz
Procymidone Prodiamine Profenofos Profluralin Propachlor Propanil
Propisochlor Propyzamide Prothiofos Pyraclofos Pyrazophos Pyridaben
Pyridaphenthion Pyrimethanil Pyriproxyfen Quinalphos Resmethrin 1 Sulfotep Sulprofos
tau-Fluvalinate 1 tau-Fluvalinate 2 Tebuconazole Tebufenpyrad Tefluthrin Terbacil Terbufos
Terbutylazine
Tetrachloroaniline, 2,3,5,6- Tetrachlorvinphos Tetradifon
Tetramethrin 1 Tetramethrin 2 Tolclofos-methyl Tolylfluanid Transfluthrin Triadimefon Triadimenol Triallate
Triazophos Triflumizole Trifluralin Vinclozolin
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