cruciferous vegetables.
1. Anti-Cancer Benefits Sulforaphane is increasingly referred to as an anticancer
compound. This reputation is linked mainly to sulforaphane's potent antioxidant and anti-inflammatory properties, not dis- similar to turmeric (curcumin). In fact, one promising, albeit preclinical study found that the combination of sulforaphane, aspirin and curcumin was effective for the chemoprevention of pancreatic cancer. It doesn't stop there, however. Sulforaphane has been stud-
ied for the prevention and treatment of several types of cancer, including stomach, bladder, breast, prostate, lung, colon and skin.
Specifically, research indicates sulforaphane "possesses the
capacity to intervene in multistage carcinogenesis through the modulation and/or regulation of important cellular mechanisms" and "to be selectively toxic to malignant cells." Other notable findings: • Evidence supports high intakes of Brassica vegetables re- duce prostate cancer risk • Potent doses of broccoli sprout extract activate a 'detoxi-
fication' gene and may help prevent cancer recurrence in survi- vors of head and neck cancer • Cruciferous contain extracts that are effective at inhibiting
lung adenocarcinomas (a malignant tumor formed from glandu- lar structures in epithelial tissue) colon polyps and skin cancer • In skin cancer research, the protection offered by sulfora-
phane "against a carcinogen in humans is catalytic and long lasting." • Broccoli sprouts have been found to be as a rich source
of antioxidants that improve the defensive system against oxida- tive stress in the human colon. In fact, in a 2015 study, 57.33% reduction in oxidative DNA damage in NCM460 cells due to treatment with digested BS extract was observed. • Combined Sulforaphane and selenium treatment enhanced
protection against free radical-mediated cell death provided by the cotreatment.
2. Depression Relief Cruciferous and sulforaphane may also have significant
benefit for depression. An animal study published in 2015 found sulforaphane "has antidepressant and anxiolytic-like [anxiety reducing] activities in stressed mice model of depression, which likely occurs by inhibiting the hypothalamic." Inflammation has also been connected to depression, and a
2016 study found broccoli sprouts effective to "prevent or mini- mize the relapse by inflammation." This same study found that the extracts of broccoli sprouts were so effective, they acted as a prophylactic that could "prevent the onset of LPS-induced depression-like behaviors" in the juvenile and adolescent mice they were testing, all the way into adulthood. [note: LPS (lipo- polysaccharide) is a bacterially derived inflammatory factor known to cause a wide range of health issues]. More research is being done on the phytochemicals of cruciferous vegetables and depression.
3. Pain Relief This is some evidence that sulforaphane may have significant
value in pain, or pain management. A 2000 study on female fi- bromyalgia patients reported that the combination of ascorbigen (derived from Vitamin C) and broccoli powder "reduces pain sensitivity and improves quality of life" for patients suffering from this challenging condition. A 2016 publication also investigated the potential for sul-
foraphane via broccoli sprout extract, noting "significant" anti- nociception [pain blocking] results, that bode well for further study into the pain relieving benefits.
4. Cardioprotection Cardiovascular problems remain a top health concern, es-
pecially in the United States. CVD, cardiovascular disease, is on the rise, with Ischemia-Reperfusion (I/R) injury (such as myocar- dial infarction ("heart attack"), stroke, and peripheral vascular disease) and hypertension being main components. Research is showing that sulforaphane helps with inflamma-
tion of the arterial walls, inhibits obesity, relieves hypertension, and other conditions that are part of or lead to CVD. With regard to hypertension, a 2012 study reported sulfora-
phane "decreases renal and vascular oxidative stress and inflam- mation as well as blood pressure", thus assisting in hypertension. r. Similarly, but even more significantly, a 2006 study demon- strated the power of eating foods high in sulforaphane by observ- ing significantly "lower blood pressure and less tissue inflamma- tion in adulthood, regardless of their subsequent diet" in the offspring of pregnant rats fed foods rich in the compound. Also of special note, a 2009 study in Iran in which rats were
given an extract containing 2% of broccoli sprouts for ten days. "[T]he results show that a relatively short dietary treatment with broccoli sprouts can strongly protect the heart against oxidative stress and cell death caused by ischemia-reperfusion." Which is
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