commensal microflora composition, elevate immune response against potential pathogens, and attenuate autoimmune re- sponses. Vitamin D deficiency in winter months, in fact, explains the seasonality of epidemic influenza.
Psoriasis and Vitiligo: Autoimmune Skin Conditions that Compromise Quality of Life
Vitiligo is an autoimmune disorder characterized by patchy
loss of skin color afflicting one percent of the world’s population. More than half of individuals suffering with vitiligo develop it before age twenty. Vitiligo can be divided into the more ubiq- uitous symmetrical form, called generalized vitiligo, and a less common segmental variety, which affects one side of the body. The former is hypothesized to represent an autoimmune condi- tion targeted against the pigment cells called melanocytes. Psoriasis, on the other hand, is an inflammatory skin disor-
der typified by painful and pruritic lesions affecting an esti- mated 125 million individuals worldwide, or two to four percent of the population. Although speculated to have an autoimmune origin, other researchers propose that psoriasis represents an abnormal response to the bacterial microbiota of the skin. Ap- proximately one out of five individuals with psoriasis report substantial dissatisfaction with treatment. Even when the red scaling plaques are not extensive, subjective accounts indicate that the psoriasis takes a substantial toll on their life. Particularly troublesome are the psychological comorbidities of vitiligo and psoriasis, as the visible manifestations can gener- ate feelings of social stigmatization and marginalization. In fact, a systematic review and meta-analysis of 1,767,583 participants, including 330,207 subjects with psoriasis, demonstrated that patients with psoriasis were twice as likely to exhibit suicidal ideation, and 26% more likely to exhibit suicidal behavior, in- cluding suicide attempts and completed suicides.
High Dose Vitamin D Induces Marked Improvements in Psoriasis and Vitiligo
In a pilot study, 35,000 IU of vitamin D3 was administered
daily to sixteen vitamin D-deficient patients with vitiligo and nine patients with psoriasis for six months in concert with a calcium-restricted diet and adequate hydration. This represents an enormous amount compared to the 1000 IU a day that many health care providers recommend, and was chosen to overcome the effects of genetic polymorphisms common in autoimmune disease.
Dosing of vitamin D3 for autoimmune cohorts often fails to take into account genetic polymorphisms related to defects in vitamin D metabolism. Polymorphisms in CYP27B1, which commonly occur in autoimmune disease, confer resistance to vitamin D such that higher circulating level of 25(OH)D3 are necessary for optimal 1,25(OH)2D3 concentrations within im- mune cells. Thus, individuals with this polymorphism may be unable to maintain the concentrations of 1,25(OH)2D3 within immune cells that are necessary for the toleragenic, anti-auto- immune effects of this steroid. However, supra-physiological, pharmacologic doses of vitamin D may be able to circumvent this genetic tendency and promote immunomodulation. In this study, dairy products and calcium-enriched foods
NATURAL Hormone Replacement Therapy
hormone our bodies make, and not synthetic ones made by the pharmaceutical industry, which can be harmful as well as helpful. With replacement, patients report an increase in their psy- chological well being. PMS symptoms can be resolved, not uncommonly, in weeks. The medical benefits are a decrease in cardiac disease, vascular disease, strokes, diabetes, Alzheimer's disease, and even cancers. Because our goal is to return hormone levels to an optimal range, we test the following for any deficiencies: Thyroid hormone, which regulates temperature, metabo-
N
lism, cerebral function, and energy levels. It can protect against cardiovascular disease, Alzheimer's disease, memory loss, fatigue and weight gain. DHEA, which stimulates the immune system, can restore
sexual vitality, improves moods, and decreases cholesterol and body fat. It improves memory, increases energy, and has anti- cancer properties by enhancing the immune system. Melatonin, which influences the quality and quantity of sleep, is also an energizer, a mood enhancer, and an antioxidant. It has also been shown to decrease the incidence of nocturia (getting up at night to urinate). Estrogen, has been proven to reduce the effects of heart
disease, stroke, high cholesterol, Alzheimer's disease, memory loss, menopausal symptoms, osteoporosis, skin thinning, the incidence of depression, and reverse the lack of libido. Progesterone, which acts as an antidepressant, mild tranquil-
izer, and natural painkiller. Bioidentical progesterone can elimi- nate symptoms of menopause, PMS emotional instability, headaches, and mood swings. Testosterone, which drops significantly in men over age 50.
This lowered level accounts for a loss of a man's sense of well- being, decrease in decrease in sex drive, loss of general muscle mass, increased abdominal obesity, osteoporosis, decrease in mental acuity, and decreased strength and endurance. And, yes, testosterone levels should be tested in women, as well. Testos- terone therapy can reverse the gradual sexual apathy that occurs over time, while also increasing energy, and strength.
Do you want to feel better? Call the number below for a consult. The $200 charge is applied to the treatment fee if you elect to go forward. The conversation you and I have may be the best investment you ever made in your health and well being!
atural hormone replacement therapy corrects the loss of our hormones that comes through aging and menopause. The term "natural hormone" means the bioidentical
Virgil V. Willard II, MD & Bandit
PIEDMONT AGE MANAGEMENT PIEDMONT PLASTIC SURGERY
1011 N. Lindsay St., Ste. 202, High Point 27262 336-886-1667
14
www.plasticsurgerync.com OCTOBER 2017
NaturalTriad.com 23
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