NO SUCH THING AS THE BEST TECHNIQUE
2. Johnson O, Palma Villar R, Nilsson LB et al. Capillary microsampling of 25 µL blood for the determination of toxicokinetic parameters in regulatory studies in animals. Bioanalysis 4(6), 661–674 (2012).
3. Bowen CL, Licea-Perez H, Karlinsey MZ et al. A novel approach to capillary plasma microsampling for quantitative bioanalysis. Bioanalysis 5(9), 1131–1135 (2013).
4. Spooner N. Latest developments in microsampling for regulated quantitative bioanalysis:
http://bcn2013.europeanbioanalysisforum.eu/slides/PDF/P2-Sam-3%20Neil%20Spooner.pdf
5. Johnsson O. Capillary Microsampling (CMS) Better science – fewer animals:
http://focus201206.europeanbioanalysisforum.eu/wp-content/uploads/2016/04/14-3-3-Ove-Jonsson.pdf
6. NC3Rs microsampling video’s:
https://www.nc3rs.org.uk/microsampling-videos
About the authors
Hans Stieltjes graduated in Organic and Analytical Chemistry at the Free University of Amsterdam, The Netherlands. After working in bioanalysis in a university hospital laboratory (4 years) and contract laboratory (CRO) for 6 years, he joined Janssen Research and Development (Beerse, Belgium) in 2004. At Janssen Research and Development Hans is working in the bioanalytical department giving support for projects in both the nonclinical and clinical stages of compound development. This also includes method development and trouble shooting for bioanalytical methods, and
giving scientific and regulatory support to colleagues and trainees. He also has an active role in outsourcing methods for new compounds, monitoring method validations and sample analysis. Besides this, he is active in implementing various microsampling procedures for nonclinical studies and scientific validation procedures for clinical studies internally and at CROs.
Tom Verhaeghe is scientific director of the Development Bioanalysis Group of Janssen Research and Development in Beerse, Belgium. In this role, Tom has global responsibility for the full range of activities in support of preclinical and clinical bioanalysis for small molecule new molecular entities ranging from method development, method validation, sample analysis, project interface support, outsourcing, and maintenance of quality and compliance standards for the group. Tom joined Janssen in 1996 with a specialty in GC–MS. Tom earned his PhD in Analytical Chemistry from KU Leuven (Belgium) in 1993.
31
www.bioanalysis-zone.com
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48
