NEW Physical and Chemical Standards Compendium
Largest Producer Worldwide of Certifi ed Reference Materials, Accredited Physical and Chemical Standards, Reagents and Control Solutions
Reagecon are proud to present their products in an innovative and informative new publication featuring:
54 Product families
8000 product references listed Presented as a Compendium
Allows the customer to access Comprehensive technical information, Product, application and production notes Commercial benefi ts Method specifi c standards (eg EPA, ASTM, Pharmacopoeias) Industry specifi c standards Accreditation, traceability and certifi cation details
Physical & Chemical Standards Compendium
TOC/TIC Standards - Premium Range
Summary of Features & Benefits: Commercial Benefits
•
• • •
Extensive range (500ppb to 20,000ppm /0.5mg/l to 20,000mg/l)
Presented in single - use glass vials Extended shelf life Ready to Use
• Offered as single vials or convenient kit format • •
Technical Benefits • •
Certified
Certificates of Analysis and Safety Data Sheets available online
Extremely high specification and purity • Manufactured in a cleanroom environment
• Vials are manufactured, cleaned and leached specifically for low level TOC standards
• •
Products manufactured from Ultra-Pure Water, produced by a special proprietary process
ISO/IEC 17025 Accreditation 500µg/L to 50mg/l (INAB Ref:264T)
In accordance with USP <643> and <1051> guidelines Consistency of product - Independent, Traceable,
Reagecon manufactures a range of Total Organic Carbon (TOC) and Total Inorganic Carbon (TIC) Standards for ease of use when calibrating all types of TOC analysers, irrespective of brand. All of our TOC standards are manufactured using high purity raw materials in accordance with USP <1051> and <643> guidelines. These products are prepared gravimetrically on a weight/weight basis. Both solute (salts) and solvent (water) are weighed on a balance calibrated by Reagecon engineers using OIML traceable weights. Reagecon holds ISO/IEC 17025 accreditation for calibration of laboratory balances (INAB Ref:265C). The resulting Balance Certificate of Calibration is issued in accordance with the requirements of ISO/IEC 17025. The TOC / TIC of the standard is verified using a high performance calibrated TOC analyser. The calibration of this instrument involves the use of high purity ISO Guide 34 accredited TOC standards similar in TOC value to the products listed in the following tables.
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To view the full scope of new offering, download our Physical and Chemical Standards Compendium and our Industry Specifi c Catalogue from our website
www.reagecon.com
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ISO Guide 34 Certified Reference Materials: Sucrose in Water Standards
ICP-MS/
Summary of Features & Benefits: Commercial Benefits
ICP-OES Standards
• •
• • •
• Ready to Use
Can be used with any brand of refractometer Extensive range (1-60% w/w Sucrose in Water
solutions) Presented in a convenient high quality dropper bottle ICP-MS/ICP-OES Standards
Reagecon have been manufacturing Inorganic Standards, Controls and Calibrators for Spectroscopy for almost two decades. During that time, the company has established itself as the most reliable primary producer of top quality standards. Our customer base in over 80 countries is testament of our efforts to be leaders in a changing field where limits of detection and purity are becoming ever more demanding. Whether your application is ICP-MS, ICP-OES or whether you require a single element or multi-element mixture, our products are manufactured, tested and stabilised to such a high level, that they can be used on all of these instruments.
ai Quality Control
All metal raw materials are assayed by titration and ICP-MS prior to manufacture. Separate CRM’s are used to control or calibrate the titration and ICP-MS respectively. This dual process enables the assays to be cross-checked against each other, provides two layers of traceability and quantifies the combined level of impurities in the starting material. The pro5duct is then manufactured gravimetrically using the mass balance approach: 100% - sum of all impurities (w/w). The assay of the final product is certified using the gravimetric result corrected for density. Prior to bottling, the finished product
BS05 BS07 BS10
S112 Certification
% Sucrose in Water (w/w) @ 20°C % Sucrose
is again tested and verified using an IBCP-MS instrument cal1ibrated with appropriate CRM’1s.1.2% Brix BS115 BS12
Reagecon’s ICP-MS and ICP-OES Standards are prepared gravimetrically on a weight/weight basis from the purest available raw materials on the market. Both solute and solvent are weighed on balances calibrated by Reagecon’s engineers using OIML traceable weights. Reagecon holds ISO/IEC 17025 accreditation for calibration of laboratory balances (INAB Ref:265C). The resulting Balance Certificate of Calibration is issued in accordance with the requirements of ISO/IEC 17025.
Traceability 328
Polychlorinated Biphenyl Standards (PCBs)
Introduction • Material.
The content of the starting material for each single element or multi-element standard is established by titration. The BS45
BS125 BS15 BS20 BS25 BS30 BS35 BS40
resulting analysis is directly traceable to a relevant NIST standard where available. All of the resulting uncertainties of BS50
measurement are calculated according to EURACHEM/CITAC guidelines and reported as expanded uncertainties at the BS55
analysis relevant to the assay of Raw Materials, for the manufacture of ICP-MS and ICP-OES standards. Verification of Raw Materials
95% confidence level. Reagecon has ISO/IEC 17025 (INAB Ref:264T) accreditation for several classes of titrimetric 1.430800 BS60
7% Sucrose 10% Sucrose 1.2% Sucrose 11.5% Sucrose 12% Sucrose 12.5% Sucrose 15% Sucrose 20% Sucrose 25% Sucrose 30% Sucrose 35% Sucrose 40% Sucrose 45% Sucrose 50% Sucrose 55% Sucrose 60% Sucrose
12.5% Brix 15% Brix 20% Brix 25% Brix 30% Brix 35% Brix 40% Brix 45% Brix 50% Brix 55% Brix 60% Brix
The concentration of the target element of each raw material is then verified using a high performance state of the art calibrated ICP-MS instrument. The calibration of the ICP-MS is completed using high purity ISO Guide 34 certified reference materials or other internationally accepted materials (e.g. BAM from Germany). This verification procedure serves three distinct but critical purposes.
Polychlorinated biphenyls (PCB’Is) are man made organic chemicals derived from combining between 1 and 10 chlorine atoms with biphenyls, a mo•lecIut ple that is composed of two benzene rings. When all of the possible positions of the chlorine atoms on the benzene rings are taken into account, a total of 209 configurations are possible and these are called congeners.
• It determines the level of trace elemental impurities in the starting raw materials.
Of these 209 congeners about 130 have been used in commercial preparations, since the introduction of the products into the marketplace by a company called Swann Chemical Company, which commenced production in 1929. Synthesis at laboratory scale began in 1881 and from then significant amounts of PCB’s were already being released into the environment.
Applications
United States Pharmacopoeia Solutions
The commercial uses of PCB’s were based on the products being good insulators, chemically stable and of low flammability. Therefore, they were used for a range of applications that include: coolants and insulating fluids for capacitors and transformers, hydraulic fluids, cutting oils, copying paper, plasticisers in paints and cements, additives in PVC coatings and as pesticide extenders. They also had a myriad of other commercial uses, description of which is beyond the scope of this document.
Enquiries from Instrument Manufacturers and Distributors welcome
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Often PCB’s were sold as commercial mixtures under trade names, including Arochlor’s, which is a brand name of Monsanto. Such Aroclor’s had a four digit numbering system, with the first two digits referring to the number of carbons in the two benzene rings (12 in the case of PCB’s) and the second two digits referred to the percentage of chlorine by mass in the mixture, although there are exceptions to this nomenclature. Aroclor’s va•ried in terms of what they were •
Summary of Features & Benefits: Commercial Benefits
used for, depending on availability and suitability for particular applications.
• • •
Free up resources for core activities Save valuable bench space
Presence in the Environment
PCB’s are highly resistant to oxidation or reduction processes, which makes them stable and persistent pollutants (POPs). developed as part of our on-going Research and Development program. These USP solutions, which are
natural destruction may lead to the generation and release of extremely toxic materials such as Dibenzodioxins and Dibenzofurans through partial oxidation.
•
Because of their lipophilic pro•perties, they are to be found in foodstuffs and at various points of the food chain. methodology
Health Effects
They are unstable in water, which makes them more stable in the environment chemically and either intentional or only available from a small number of manufacturers, bring you multiple benefits that include:
Many rivers, lakes, buildings a•nd other sites are contaminated by PCB’s and they have been found also in soil and air. Produced according to relevant Pharmacopoeia requirements - no deviation in materials or
However, most human absorption is through the alimentary or respiratory routes and once ingested they may change in chemical structure. One of the physical properties of PCB’s includes lipophilicity which causes bioaccumulation in both adipose tissue and in liver tissue.
For USP products not listed below, please contact us at
sales@reagecon.ie
Persons exposed to very high levels may experience skin lesions, liver damage, ocular lesions, lowered immunity and Product irregular menstrual cycles by interference with estradiol. Generalised symptoms can include headaches, fatigue and No. 100ml cough. More severe symptomatiUc outcomes may include cancers, sexual, skeletal, and mental under-development in USP0101
Description SP Solution Acetate Buffer TS Conforms to USP
both sexes. In fact, evidence of reduced levels of certain thyroid hormones could have an adverse effect on every USP0201 physiological process within the body.
USP Solution Acetic Acid 2.00 Normal Conforms to USP
USP Solution Acetic Acid-Ammonium Acetate Buffer TS Conforms to USP USP Solution Ammonia-Ammonium Chloride Buffer TS Conforms to USP USP Solution Ammoniacal Potassium Ferricyanide TS Conforms to USP USP Solution Ammonium Carbonate TS Conforms to USP USP Solution Ammonium Chloride TS Conforms to USP
USP Solution Ammonium Chloride-Ammonium Hydroxide TS Conforms to USP USP Solution Ammonium Thiocyanate TS Conforms to USP USP Solution Barium Chloride TS/RS Conforms to USP USP Solution Barium Nitrate TS Conforms to USP
USP Solution Bromate-Bromide Solution 0.100 Normal Conforms to USP USP Solution Bromocresol Green TS Conforms to USP USP Solution Bromocresol Purple TS Conforms to USP USP Solution Bromophenol Blue TS Conforms to USP USP Solution Bromothymol Blue TS Conforms to USP
USP0301 USP0401 USP0501 USP0601 USP0701 USP0801 USP0901 USP1001 USP1101 USP1201 USP1301 USP1401 USP1501 USP1601
Product
No. 500ml USP0105 USP0205 USP0305 USP0405 121
USP0505 USP0605 USP0705 USP0805 USP0905 USP1005 USP1105 USP1205 USP1305 USP1405 USP1505 USP1605
337
PCB’s are readily absorbed through skin, but can also be absorbed through polyvinyl chloride (PVC) or latex rubber. in-house preparations cannot provide
Significant reduction in the amount of time and expense required to prepare Test Solutions Ensure consistency of products (independent, traceable Certificates of Analysis)
• Manufactured with controlled processes and batch certified to ensure lot-to-lot consistency and reproducibility of results. Such benefits give you the assurance and peace of mind that
Reagecon is pleased to announce a new range of USP ready to use solutions. These solutions have been Reduce preparation time
Technical Benefits •
Produced in accordance with USP methods
Consistency of product - Independent, Traceable, Certified Certificates of Analysis and Safety Data Sheets available online
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t p ovides a completely independent check of the accuracy and validity of the titration assay. rovides traceability by comparison to a second reference, which is independent from the first Reference
1.441928 *The nominal Brix and Refractive Index values are taken from the ICUMSA published tables
11.5% Brix 12% Brix
7% Brix 10% Brix
ISO Guide 34 Sucrose in Water Standards (INAB Ref:001RM) -12 Week Shelf Life Product No.
) -
Nominal Brix %* 5% B x
Nominal Refractive Index @ 20°C 1.340264
1.343253 1.347824 1.349682 1.350149 1.350930 1.351714 1.355679 1.363842 1.372328 1.381149 1.390322 1.399860 1.409777 1.420087
Pack size 15ml
15ml 15ml 15ml 15ml 15ml 15ml 15ml 15ml 15ml 15ml 15ml 15ml 15ml 15ml 15ml 15ml
329
Reagecon now manufacture a range of Sucrose in Water solutions in compliance with ISO Guide 34 (INAB Ref:001RM). This is an internationally recognised accreditation for the production of certified reference materials. It delivers the highest level of quality assurance possible, and provides the customer with full confidence that the manufacturer's standards are produced correctly and competently in a sound metrological fashion. ISO Guide 34 accreditation requirements includes production planning, material selection, assignment of certified values, uncertainty, traceability, homogeneity and stability, as well as packaging and documentation. These standards are certified by gravimetric preparation, with an uncertainty of measurement of < 0.15% w/w, and include an equivalent % Brix and refractive index value.
ve Customised pack options available k o
Extended shelf life - 12 weeks - (Manufactured inaccordance with ICUMSA guidelines)
•
• • •
Technical Benefits e 3
s u f p f A
ISO Guide 34 Compliant (INAB Ref:001RM)
• Measurement uncertainty computated on a batch by basis under these guidelines
d R y batch
Consistency of product - Independent, Traceable, Certified Certificates of Analysis and Safety Data Sheets available This Certified Reference Material is intended primarily as
either a calibrant or analytical control solution for use in Refractive IIndex based methods of Brix value determination
r a c e e d
y e
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