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New Process for the Production of Uniform Particle Size Chromatography Resin Beads
Announced Purolite today announces its patented continuous process – Jetting - for the production of uniform particle size chromatography resins using two propriety manufacturing processes.
For liquid chromatography (size exclusion chromatography, ion exchange chromatography, hydrophobic interaction chromatography, reversed phase chromatography, solid phase extraction, and affinity chromatography) it is preferable to
Traditional batch emulsifi cation particle size distribution (left) compared with uniform resin beads produced via Purolite’s Jetting technology (right)
have uniform particle size beads to provide improved kinetics, resolution, performance consistency and superior packing properties.
Classic batch emulsion polymerisation is a robust, proven technology which results in a relatively broad (Gaussian) particle size distribution. Jetting, however, is a continuous, direct manufacturing process for chromatographic resin beads with a narrow particle size distribution, resulting in higher yields and superior economics. Jetting allows for chromatographic resins to be produced relatively quickly in small or large quantities (>1000Kg) as required. The availability of consistent supplies of large volumes of chromatographic resin beads also opens up the possibility of new potential larger scale applications.
The first Purolite jetting process - membrane or ‘can’ jetting - entails using a membrane with very small, discrete orifices, through which the polymer is passed. This device is capable of producing uniform particle size chromatographic resins from ~15 to 250 micron.
The second process, plate jetting, utilises a plate with many precisely engineered holes, through which the resin polymer is passed. Uniform particle size chromatographic resins of ~150 µm to >1000µm can be produced using this method.
For more information, please contact
lifesciences@purolite.com
New Columns Provide Better Separations of Monoclonal Antibodies, Large Proteins and Synthetic Polymers
Advanced Materials Technology have launched a new tool in the BioClass Fused-Core HPLC/UHPLC columns family specifically designed for the separation of large molecules such as monoclonal antibodies, large proteins and synthetic polymers.
New HALO 1000Å C4 columns contain the world’s first 2.7 micron superficially porous silica particles with 1000 Angstrom pores. The pore size and structure of these particles enable molecules to achieve complete penetration of the porous structure, allowing them to interact with more of the bonded surface for better retention and selectivity. This new ‘Total Access Pore Technology’ results in improved separations of these types of large molecules. Application notes and a technical brochure are available and demonstrate the ability of HALO 1000Å C4 to provide valuable detailed information not possible to achieve when using particles with smaller pore sizes.
For more information or a copy of the technical brochure email
technical@hichrom.co.uk
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