46 February / March 2017 Conclusions
The method developed in this study for screening saliva samples presents an alternative to current methods with a number of signifi cant benefi ts. Taking saliva samples presents an easier, non-invasive sampling procedure which benefi ts the patient. A BioSPME extraction followed by DART-MS analysis resulted in acceptable measurement accuracies at 100, 500, and 1000 ng/ mL for fentanyl and some of its related analogue compounds. By eliminating steps that are necessary in some of the more extensive SPE procedures (i.e. elution and evaporation), the BioSPME method obtained reproducible and accurate results in less time. While not an exhaustive extraction technique, BioSPME still enables concentration of the analyte onto the fi bre; thus lowering the detection limits that can sometimes be an obstacle with dilute and shoot methods. Incorporation of direct MS analysis with the
DART-QDa system, enabled analytical results in seconds, and with no solvent usage as compared to HPLC analyses. Combining the simple BioSPME extraction procedure with DART-MS produced a fast, reproducible screening method for high throughput analysis of saliva samples.
References
1. Mohr, A., Frisca, M., et. Al., (2016) Analysis of novel synthetic opioids U-47700, U-50488 and Furanyl Fentanyl by LC–MS/MS in postmortem casework, Journal of Analytical Toxicology, 40, 709-717
2. Shaner, R., Kaplan, P., et. Al., (2014) Comparison of two automated solid phase extractions for thedetection of ten fentanyl analogs and metabolites in human urine using liquid chromatography tandem mass spectrometry, Journal of Chromatography B, 962, 52-58
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