QF Focus Magazine
The Clean Room includes different security systems to make sure that the cells that they work on are not contaminated with microorganisms or particles. These include the following: • The air that enters the lab is sterile, and has been filtered to eliminate suspended particles and microorganisms. It is completely replaced several times an hour, so dust cannot accumulate. It circulates through high-efficiency particulate arresting (HEPA) filters that retain particles. • The production area and entry changing rooms are kept on a decreasing pressure level scale between each room and the outside, so that when doors are opened, air always comes out, and cannot go in. Movement between the different areas of the room involves a sluice-gate system to preserve the pressure differences between the areas and between the Clean Room and the outside. • The walls are covered in phenolic resin and their corners are rounded to prevent dirt accumulation. In addition, there are no water faucets or drains inside, since these are microbial contamination loci. • The entry and exit of material and reactive substances takes place through a pressurised sluice system separate from the personnel gates; this prevents possible cross-contamination with the products made in the room.
Other Applications of Cellular Therapy Other applications of cellular therapy that can be developed in the Clean Room, in addition to oncology, include cellular therapy with mesenchymal stem cells (MSCs). MSCs are multipotent progenitor cells derived from bone marrow or fatty tissue, which are capable of differentiating from other cells of mesodermal origin (cartilage, muscle, bone and other cells). In fact, they can be used to treat cardiovascular or liver diseases, multiple sclerosis, rheumatoid arthritis, Crohn’s disease, and even regenerate joint tissue, among other uses.
It can also be used in the creation of antiangiogenic therapy for treating severe ischemias, such as Buerger’s disease, regenerative therapy with autologous limbocorneal cells to fight limbal stem cell deficiency, regenerative therapy with autologous epidermic sheets for epidermic regeneration (burn victims) or regenerative therapy with skeletal myoblasts, which have been used for regenerative medicine in patients with cardiovascular diseases in acute states, such as myocardial infarction, or in chronic states, such as coronary heart disease.
Page 13
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36